Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM6CVZ5)

Drug Name
Bavisant Drug Info
Synonyms JNJ-31001074
Cross-matching ID
PubChem CID
16061509
ChEBI ID
CHEMBL2103862
CAS Number
CAS 929622-08-2
TTD Drug ID
D0M8OC

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Synthesis and degradation of ketone bodies 1.93 1.65e-2 9/10 (90%) HMGCS1;ACAT2;BDH2
Mismatch repair 1.90 8.27e-3 22/23 (95.65%) PCNA;RFC5;RFC3;...
DNA replication 1.84 1.65e-2 34/36 (94.44%) PCNA;MCM5;RFC5;...
Valine, leucine and isoleucine degradation 1.79 3.72e-2 42/48 (87.5%) ABAT;DLD;HMGCS1;...
PPAR signaling pathway 1.78 3.80e-2 66/74 (89.19%) FABP7;HMGCS1;FADS2;...
Cell cycle 1.76 4.13e-2 110/124 (88.71%) PCNA;CCND2;CDC20;...
TGF-beta signaling pathway -1.60 4.99e-2 81/94 (86.17%) E2F5;BMPR1B;TGIF1;...
Kaposi sarcoma-associated herpesvirus infection -1.62 4.79e-2 172/193 (89.12%) MICA;BECN1;GNB1;...
Legionellosis -1.63 4.79e-2 51/57 (89.47%) CR1;HSPA6;CASP7;...
Neutrophil extracellular trap formation -1.63 4.85e-2 101/189 (53.44%) SLC25A5;MPO;CASP1;...
N-Glycan biosynthesis -1.63 4.90e-2 38/50 (76%) ALG13;DPAGT1;ALG12;...
Central carbon metabolism in cancer -1.64 4.86e-2 67/70 (95.71%) PIK3CA;PFKM;PDHA1;...
Malaria -1.65 4.62e-2 44/50 (88%) GYPA;SDC2;CD40;...
Lipid and atherosclerosis -1.66 4.49e-2 190/215 (88.37%) IRF3;MMP1;BAD;...
C-type lectin receptor signaling pathway -1.66 4.61e-2 93/104 (89.42%) PPP3CC;PTGS2;IL6;...
B cell receptor signaling pathway -1.70 3.63e-2 71/81 (87.65%) CD79B;PPP3CC;LILRA1;...
Toxoplasmosis -1.72 3.26e-2 103/112 (91.96%) HLA-DMB;PIK3R5;NFKB1;...
Epithelial cell signaling in Helicobacter pylori infect... -1.72 3.40e-2 62/70 (88.57%) NFKB1;ATP6V1D;CXCL8;...
Th17 cell differentiation -1.74 3.22e-2 95/107 (88.79%) IL2RB;HLA-DOB;PPP3CC;...
Chemokine signaling pathway -1.75 3.19e-2 163/192 (84.9%) GNB1;PF4V1;CRKL;...
Asthma -1.75 3.46e-2 25/31 (80.65%) HLA-DOA;TNF;MS4A2;...
Toll-like receptor signaling pathway -1.81 2.05e-2 94/104 (90.38%) TLR5;IRF3;CD40;...
Tuberculosis -1.82 2.25e-2 159/180 (88.33%) HLA-DOB;HSPD1;CD14;...
NF-kappa B signaling pathway -1.82 2.50e-2 90/104 (86.54%) PLCG2;LCK;BTK;...
Primary immunodeficiency -1.83 2.67e-2 33/38 (86.84%) CD8B;CD3D;LCK;...
IL-17 signaling pathway -1.88 1.19e-2 84/94 (89.36%) CXCL6;PTGS2;CEBPB;...
Osteoclast differentiation -1.89 1.19e-2 117/127 (92.13%) PLCG2;LCK;BTK;...
Hematopoietic cell lineage -1.93 9.48e-3 90/99 (90.91%) CD1E;IL1R1;CD33;...
Cytokine-cytokine receptor interaction -1.94 1.19e-2 246/295 (83.39%) TNFRSF4;TNFRSF21;ACVR2B;...
Viral protein interaction with cytokine and cytokine re... -2.02 7.90e-3 84/100 (84%) IL2RB;CCR1;CCL24;...
TNF signaling pathway -2.03 5.93e-3 103/112 (91.96%) CXCL6;PTGS2;FAS;...
Rheumatoid arthritis -2.29 0.00e+0 78/93 (83.87%) CTSK;HLA-DOB;CXCL6;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 2.22uM 24H