Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM6EUL5)

Drug Name
Betaxolol Drug Info
Synonyms
Betaxololum; Betazolol; KERLEDEX; Kerlone; Betaxolol HCL; SL 75212; Betaxolol (INN); Betaxolol (TN); Betaxolol [INN:BAN]; Betaxololum [INN-Latin]; Betoptic (TN); Betoptic S (TN); Kerlone (TN); Lokren (TN); SL-75212; ALO-1401-02; (+/-)-1-[p-[2-(Cyclopropylmethoxy)ethyl]phenoxy]-3-(isopropylamino)-2-propanol; 1-(4-(2-(Cyclopropylmethoxy)ethyl)phenoxy)-3-((1-methylethyl)amino)-2-propanol; 1-(isopropylamino)-3-[p-(cyclopropylmethoxyethyl)phenoxy]-2-propanol; 1-[(4-{2-[(cyclopropylmethyl)oxy]ethyl}phenyl)oxy]-3-[(1-methylethyl)amino]propan-2-ol; 1-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-3-(propan-2-ylamino)propan-2-ol; 1-{4-[2-(cyclopropylmethoxy)ethyl]phenoxy}-3-(propan-2-ylamino)propan-2-ol
Therapeutic ClassAntihypertensive Agents
Cross-matching ID
PubChem CID
2369
ChEBI ID
CHEMBL423
CAS Number
CAS 63659-18-7
TTD Drug ID
D03ROX
INTEDE Drug ID
DR0206
ACDINA Drug ID
D00065

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Cell cycle 1.95 3.88e-2 110/124 (88.71%) CHEK2;E2F5;CCNE2;...
DNA replication 1.88 2.91e-2 34/36 (94.44%) PCNA;SSBP1;RFC3;...
Mucin type O-glycan biosynthesis 1.83 3.01e-2 20/36 (55.56%) B4GALT5;GALNT6;GALNT11;...
Ribosome 1.83 2.26e-2 113/158 (71.52%) MRPL12;RPL26L1;MRPL15;...
Nucleotide excision repair 1.74 4.91e-2 40/47 (85.11%) RBX1;PCNA;RAD23B;...
Homologous recombination 1.71 4.95e-2 35/41 (85.37%) RBBP8;SSBP1;RAD51;...
Biosynthesis of unsaturated fatty acids -1.67 4.47e-2 21/27 (77.78%) ACOT7;HACD2;HSD17B4;...
Staphylococcus aureus infection -1.67 4.72e-2 72/95 (75.79%) HLA-DRA;HLA-DPA1;FPR1;...
Adipocytokine signaling pathway -1.68 4.54e-2 64/69 (92.75%) NFKBIB;RELA;ACACB;...
PPAR signaling pathway -1.69 4.59e-2 66/74 (89.19%) ME3;PLIN1;ACOX2;...
HIF-1 signaling pathway -1.69 4.55e-2 105/109 (96.33%) FLT1;PFKFB3;EGLN3;...
Ferroptosis -1.70 4.05e-2 36/41 (87.8%) ACSL4;CYBB;FTL;...
Fat digestion and absorption -1.71 3.86e-2 35/43 (81.4%) DGAT1;PLPP3;APOA1;...
Insulin signaling pathway -1.73 3.43e-2 121/137 (88.32%) INSR;PIK3R2;CRK;...
Ubiquinone and other terpenoid-quinone biosynthesis -1.73 3.63e-2 9/11 (81.82%) GGCX;COQ3;VKORC1;...
Central carbon metabolism in cancer -1.74 3.60e-2 67/70 (95.71%) HK3;EGFR;IDH1;...
Steroid biosynthesis -1.79 2.43e-2 19/20 (95%) EBP;FDFT1;MSMO1;...
Hematopoietic cell lineage -1.80 2.57e-2 90/99 (90.91%) CD37;HLA-DRA;FCER2;...
Thyroid cancer -1.81 1.29e-2 36/37 (97.3%) GADD45A;CDH1;RXRA;...
Nitrogen metabolism -1.86 1.29e-2 16/17 (94.12%) CA6;GLUD2;CA12;...
Pentose and glucuronate interconversions -1.90 1.03e-2 17/34 (50%) AKR1A1;UGDH;AKR1B10;...
Galactose metabolism -1.91 9.65e-3 26/31 (83.87%) HK3;PFKM;HK1;...
Glycolysis / Gluconeogenesis -1.92 1.29e-2 56/67 (83.58%) ALDOA;FBP1;HK3;...
Fructose and mannose metabolism -2.03 0.00e+0 30/33 (90.91%) KHK;TKFC;PFKFB3;...
Mineral absorption -2.19 0.00e+0 48/60 (80%) FTL;SLC31A1;ATP2B1;...
×

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 10uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H