Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM6FG1P)

Drug Name
Doxercalciferol Drug Info
Synonyms
Doxcercalciferol; Hectorol; Doxercalciferol [INN]; TSA 840; BCI-101; Doxercalciferol (INN); Hectorol (TN); (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(E,2R,5R)-5,6-dimethylhept-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol; (5Z,7E,22E)-9,10-Secoergosta-5,7,10(19),22-tetraene-1alpha,3beta-diol; 1-Hydroxyergocalciferol; 1-alpha-Hydroxyvitamin D2; 1alpha-Hydroxyergocalciferol; 1alpha-OH-D2; 9,10-Secoergosta-5,7,10(19),22-tetraene-1,3-diol,(1-alpha,3-beta,5Z,7E,22E)
Cross-matching ID
PubChem CID
5281107
ChEBI ID
CHEMBL1200810
CAS Number
CAS 54573-75-0
TTD Drug ID
D0G5CF
INTEDE Drug ID
DR1757
ACDINA Drug ID
D00214

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Tyrosine metabolism -1.70 4.71e-2 30/36 (83.33%) TYRP1;MAOA;DBH;...
Carbohydrate digestion and absorption -1.73 3.14e-2 37/47 (78.72%) GNAT3;PIK3CA;PLCB4;...
Phenylalanine metabolism -1.74 3.36e-2 14/17 (82.35%) MAOA;PAH;DDC;...
Tryptophan metabolism -1.76 3.70e-2 35/42 (83.33%) MAOA;ECHS1;KYNU;...
Viral protein interaction with cytokine and cytokine re... -1.86 6.73e-3 84/100 (84%) CCR9;CCL23;CCR3;...
Mineral absorption -1.87 6.73e-3 48/60 (80%) FXYD2;HEPH;MT2A;...
Proteasome -1.89 0.00e+0 44/46 (95.65%) PSMA6;PSMC4;PSME4;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H