Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM6I5GR)

Drug Name
Promethazine Drug Info
Synonyms
Antiallersin; Aprobit; Avomine; Camergan; Dimapp; Diphergan; Diprazin; Diprazine; Diprozin; Fargan; Fenazil; Fenetazina; Fenetazine; Genphen; Hiberna; Histargan; Iergigan; Isophenergan; Isopromethazine; Lercigan; Lergigan; Metaryl; Pelpica; Phargan; Phenargan; Phenerzine; Phensedyl; Pilothia; Pilpophen; Pipolphene; Proazaimine; Proazamine; Procit; Promacot; Promazinamide; Promergan; Promesan; Prometasin; Prometazin; Prometazina; Prometazine; Prometh; Promethacon; Promethaine; Promethazin; PromethazineHcl; Promethazinum; Promethegan; Promethiazine; Promezathine; Prorex; Protazine; Prothazin; Prothazine; Provigan; Pyrethia; Pyrethiazine; Remsed; Romergan; Rumergan; Tanidil; Thiergan; Valergine; Vallergine; Lilly 01516; Lilly 1516; RP 3277; SKF 1498; WY 509; A-91033; Atosil (TN); Avomine (TN); Fargan (TN); Farganesse (TN); Lergigan (TN); Phenergan (TN); Phenoject-50; Pro-50; Prometazina [INN-Spanish]; Promethazine [INN:BAN]; Promethazinum [INN-Latin]; Promethegan (TN); Prothiazine (TN); Receptozine (TN); Romergan (TN); Zipan-25; Dimethylamino-isopropyl-phenthiazin; Dimethylamino-isopropyl-phenthiazin [German]; Promethazine (JAN/INN)
Therapeutic ClassAntiallergic Agents
Cross-matching ID
PubChem CID
4927
ChEBI ID
CHEMBL643
CAS Number
CAS 60-87-7
TTD Drug ID
D0T2XU
VARIDT Drug ID
DR00674
INTEDE Drug ID
DR1353
ACDINA Drug ID
D00561

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid biosynthesis 2.09 0.00e+0 19/20 (95%) SQLE;MSMO1;CYP51A1;...
Cell cycle 1.98 1.07e-2 110/124 (88.71%) PLK1;CCNB2;CCNB1;...
ECM-receptor interaction 1.94 1.43e-2 80/88 (90.91%) COL1A2;COL4A2;ITGA6;...
Ribosome biogenesis in eukaryotes 1.87 2.15e-2 52/108 (48.15%) GAR1;NOP56;GNL3;...
Histidine metabolism -1.66 4.70e-2 16/22 (72.73%) AOC1;HNMT;ALDH3A2;...
Glycosylphosphatidylinositol (GPI)-anchor biosynthesis -1.69 4.53e-2 20/26 (76.92%) PIGP;PIGV;PIGN;...
Caffeine metabolism -1.69 4.87e-2 5/6 (83.33%) CYP2A6;CYP1A2;NAT1
Phenylalanine metabolism -1.76 2.87e-2 14/17 (82.35%) PAH;MIF;TAT;...
Arginine biosynthesis -1.77 3.44e-2 17/22 (77.27%) ASL;GOT2;GLS2;...
Fatty acid degradation -1.77 4.08e-2 40/43 (93.02%) ACSL1;ALDH9A1;GCDH;...
Primary immunodeficiency -1.83 1.81e-2 33/38 (86.84%) TAP1;RAG1;TAP2;...
Mitophagy -2.07 0.00e+0 56/68 (82.35%) NBR1;USP8;OPTN;...
Glycine, serine and threonine metabolism -2.35 0.00e+0 31/40 (77.5%) BPGM;SHMT1;GNMT;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 6.66uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 6.66uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CL-34 CVCL_1123 Homo sapiens 6.66uM 6H
HT-29 CVCL_0320 Homo sapiens 6.66uM 6H, 24H
LoVo CVCL_0399 Homo sapiens 6.66uM 6H
MDST8 CVCL_1400 Homo sapiens 6.66uM 6H
NCI-H508 CVCL_1561 Homo sapiens 6.66uM 6H
SNU-1040 CVCL_5001 Homo sapiens 6.66uM 6H
SNU-C4 CVCL_5008 Homo sapiens 6.66uM 6H
SNU-C5 CVCL_5009 Homo sapiens 6.66uM 6H
SW480 CVCL_0546 Homo sapiens 6.66uM 6H
SW620 CVCL_0547 Homo sapiens 6.66uM 6H
SW948 CVCL_0550 Homo sapiens 6.66uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 6.66uM 6H
HT115 CVCL_1294 Homo sapiens 6.66uM 6H
RKO CVCL_0504 Homo sapiens 6.66uM 6H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 6.66uM 6H
SNG-M CVCL_1707 Homo sapiens 6.66uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 6.66uM 6H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 6.66uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 1.25uM - 40uM 3H, 6H, 24H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 12uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 6.66uM 6H, 24H
DV-90 CVCL_1184 Homo sapiens 6.66uM 6H
SK-LU-1 CVCL_0624 Homo sapiens 6.66uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 6.66uM 6H
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 6.66uM 6H
T3M-10 CVCL_1729 Homo sapiens 6.66uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC15 CVCL_1253 Homo sapiens 6.66uM 6H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 6.66uM 6H
HCC515 CVCL_5134 Homo sapiens 6.66uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 6.66uM 6H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1694 CVCL_1495 Homo sapiens 6.66uM 6H
NCI-H1836 CVCL_1502 Homo sapiens 6.66uM 6H
Lymph node
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WSU-DLCL2 CVCL_1787 Homo sapiens 6.66uM 6H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 6.66uM 6H
OV7 CVCL_1623 Homo sapiens 6.66uM 6H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RMG-I CVCL_1663 Homo sapiens 6.66uM 6H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 6.66uM 6H
RMUG-S CVCL_1666 Homo sapiens 6.66uM 6H
Ovarian undifferentiated carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TYK-nu CVCL_1774 Homo sapiens 6.66uM 6H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 6.66uM 6H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NOMO-1 CVCL_1609 Homo sapiens 6.66uM 6H
PL-21 CVCL_2161 Homo sapiens 6.66uM 6H
SKM-1 CVCL_0010 Homo sapiens 6.66uM 6H
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 6.66uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 6.66uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 6.66uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 6.66uM 6H, 24H
SK-MEL-1 CVCL_0523 Homo sapiens 6.66uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 6.66uM 6H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 6.66uM 6H