Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM6IRN4)

Drug Name
[3H]RX821002 Drug Info
Synonyms
2-Methoxyidazoxan; RX-821002; RX 821002; 102575-24-6; RX821002; alpha-methoxyidazoxan; RX 821001; CHEMBL10332; CHEBI:73287; 2-(2,3-Dihydro-2-methoxy-1,4-benzodioxin-2-yl)-4,5-dihydro-1H-imidazole; 1H-Imidazole, 2-(2,3-dihydro-2-methoxy-1,4-benzodioxin-2-yl)-4,5-dihydro-; 2-[2-(2-methoxy-1,4-benzodioxanyl)]imidazoline; 2-(2-methoxy-2,3-dihydro-1,4-benzodioxin-2-yl)-4,5-dihydro-1H-imidazole; [3H]2-methoxyidazoxan; 2-(2-methoxy-3H-1,4-benzodioxin-2-yl)-4,5-dihydro-1H-imidazole; 2-ethoxy-idazoxan; PubChem2676; Spectrum_001808; [3H]2-methoxyidazoxan
Cross-matching ID
PubChem CID
108094
ChEBI ID
CHEMBL10332
CAS Number
CAS 102575-24-6
TTD Drug ID
D08KLH

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Other glycan degradation -1.83 1.96e-2 13/18 (72.22%) ENGASE;MAN2B2;HEXA;...
Lysosome -1.85 1.99e-2 115/128 (89.84%) ABCA2;CD164;LITAF;...
Steroid biosynthesis -1.93 1.13e-2 19/20 (95%) HSD17B7;EBP;CYP51A1;...
Regulation of lipolysis in adipocytes -1.96 1.21e-2 52/55 (94.55%) LIPE;ADCY3;ADRB2;...
Biosynthesis of unsaturated fatty acids -1.96 1.36e-2 21/27 (77.78%) SCD5;TECR;HACD2;...
Mineral absorption -2.53 0.00e+0 48/60 (80%) ATP1B3;ATP1B2;ATP2B2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H, 24H