Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM6KVIA)

• Drug Name: PF-3644022 Drug Info
• Synonyms: PF3644022; PF 3644022
• Cross-matching ID:
  PubChem CID: 44631903
  ChEBI ID: CHEMBL1231206
  TTD Drug ID: D06QBJ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
DNA replication	2.01	0.00e+0	34/36 (94.44%)	RFC3;POLE3;POLA1;...
Fructose and mannose metabolism	-1.92	6.70e-3	30/33 (90.91%)	PFKM;PFKL;GMPPA;...
Galactose metabolism	-1.95	1.34e-2	26/31 (83.87%)	GALK1;G6PC3;HKDC1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	1.11uM - 10uM	24H	Hide ▲

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	1.11uM - 10uM	24H	Hide ▲