General Information of Drug (ID: DM6LPIG)

Drug Name
BMS-265246 Drug Info
Synonyms BMS 265246; BMS265246
Cross-matching ID
PubChem CID
135402864
ChEBI ID
CHEMBL310840
CAS Number
CAS 582315-72-8
TTD Drug ID
D05SZH

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
Citrate cycle (TCA cycle) 2.20 0.00e+0 30/30 (100%) IDH2;PCK2;IDH1;...
Fatty acid elongation 1.97 0.00e+0 19/27 (70.37%) ELOVL6;HACD1;ELOVL1;...
Peroxisome 1.95 2.49e-3 72/82 (87.8%) PHYH;IDH2;ACAA1;...
Valine, leucine and isoleucine degradation 1.92 3.74e-3 42/48 (87.5%) ACAT1;ACAA1;ACAT2;...
Homologous recombination 1.87 7.48e-3 35/41 (85.37%) RBBP8;BABAM2;RPA2;...
Fanconi anemia pathway 1.86 9.97e-3 36/54 (66.67%) HES1;MLH1;RPA2;...
Galactose metabolism 1.85 1.07e-2 26/31 (83.87%) AKR1B10;PFKL;PGM1;...
Steroid biosynthesis 1.79 1.68e-2 19/20 (95%) MSMO1;SC5D;DHCR7;...
Terpenoid backbone biosynthesis 1.79 1.50e-2 18/22 (81.82%) ACAT1;IDI1;ACAT2;...
Biosynthesis of unsaturated fatty acids 1.79 1.42e-2 21/27 (77.78%) ELOVL6;ACAA1;HACD1;...
Glutathione metabolism 1.79 1.29e-2 43/57 (75.44%) GSTM3;IDH2;IDH1;...
Fatty acid degradation 1.78 1.31e-2 40/43 (93.02%) ACAT1;ACAA1;ACAT2;...
Tryptophan metabolism 1.76 1.73e-2 35/42 (83.33%) ACAT1;CYP1B1;ACAT2;...
Pyruvate metabolism 1.75 1.66e-2 41/47 (87.23%) ACAT1;PCK2;ACAT2;...
Other glycan degradation 1.74 1.64e-2 13/18 (72.22%) GLB1;MANBA;HEXA;...
Folate biosynthesis 1.72 2.01e-2 23/26 (88.46%) GCH1;AKR1B10;QDPR;...
Butanoate metabolism 1.71 2.11e-2 23/28 (82.14%) ACAT1;ACAT2;HMGCS1;...
Glycolysis / Gluconeogenesis 1.71 1.99e-2 56/67 (83.58%) PCK2;PFKL;PGM1;...
Synthesis and degradation of ketone bodies 1.67 3.03e-2 9/10 (90%) ACAT1;ACAT2;HMGCS1;...
Pentose and glucuronate interconversions 1.66 3.10e-2 17/34 (50%) AKR1B10;KL;SORD;...
Metabolism of xenobiotics by cytochrome P450 1.65 3.13e-2 49/77 (63.64%) GSTM3;CYP1B1;GSTK1;...
Nucleotide excision repair 1.65 3.06e-2 40/47 (85.11%) CCNH;GTF2H4;RFC2;...
Alanine, aspartate and glutamate metabolism 1.62 4.03e-2 27/37 (72.97%) CPS1;ASS1;ABAT;...
Pentose phosphate pathway 1.61 4.14e-2 25/30 (83.33%) PFKL;RBKS;PGM1;...
Glyoxylate and dicarboxylate metabolism 1.59 4.40e-2 23/30 (76.67%) ACAT1;ACAT2;AMT;...
×

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone marrow
Chronic myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HAP1 CVCL_Y019 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 CDK4 (-) 1 CVCL_SI36 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 HDAC5 (-) 1 CVCL_SR11 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 ITGA4 (-) 1 CVCL_ST27 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 MAPK8 (-) 1 CVCL_SW99 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PIK3CA (-) 1 CVCL_TD60 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PRKACA (-) 1 CVCL_TG70 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PRKCQ (-) CVCL_TG92 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 RELA (-) 1 CVCL_TI75 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 SRC (-) 1 CVCL_TQ36 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 TP53 (-) 1 CVCL_RJ70 Homo sapiens 0.66uM - 3.33uM 24H
Breast
Fibrocystic breast disease
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A (Parent) CVCL_0598 Homo sapiens 1.11uM - 10uM 3H, 6H, 12H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 1.11uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.66uM - 10uM 24H