Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM6OFJ8)

Drug Name
Indibulin Drug Info
Synonyms
Indibulin; 204205-90-3; 2-(1-(4-chlorobenzyl)-1H-indol-3-yl)-2-oxo-N-(pyridin-4-yl)acetamide; d-24851; UNII-80K4H2RB8P; 80K4H2RB8P; ZIO-301; D 24851; 2-[1-(4-chlorobenzyl)-1h-indol-3-yl]-2-oxo-n-(pyridin-4-yl)acetamide; N-(Pyridin-4-yl)-[1-(4-chlorobenzyl)-indol-3-yl]-glyoxyl Amide; Indibulin [USAN:INN]; 2-{1-[(4-chlorophenyl)methyl]indol-3-yl}-2-oxo-N-(4-pyridyl)acetamide; 2-[1-[(4-chlorophenyl)methyl]indol-3-yl]-2-oxo-N-(4-pyridyl)acetamide; Indibulin (USAN/INN); AC1L1ESK; AC1Q5NS8; MLS006011745; CHEMBL49642
Cross-matching ID
PubChem CID
2929
ChEBI ID
CHEMBL49642
CAS Number
CAS 204205-90-3
TTD Drug ID
D04NXL

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Ribosome biogenesis in eukaryotes 2.09 1.07e-2 52/108 (48.15%) REXO2;RPP40;NVL;...
ECM-receptor interaction 1.97 1.07e-2 80/88 (90.91%) ITGA6;LAMB1;ITGA3;...
Focal adhesion 1.90 2.14e-2 180/201 (89.55%) ACTN1;ITGA6;PRKCA;...
Amoebiasis 1.82 2.68e-2 99/102 (97.06%) CXCL3;ACTN1;CXCL2;...
Primary bile acid biosynthesis -1.60 4.61e-2 15/17 (88.24%) CYP27A1;HSD17B4;SCP2;...
PPAR signaling pathway -1.61 4.73e-2 66/74 (89.19%) ACADM;ACSBG1;EHHADH;...
Type I diabetes mellitus -1.62 4.56e-2 38/43 (88.37%) HLA-DMB;GAD2;PTPRN2;...
Tyrosine metabolism -1.63 4.46e-2 30/36 (83.33%) ADH1A;DCT;GSTZ1;...
Collecting duct acid secretion -1.68 2.47e-2 22/27 (81.48%) ATP6V1D;ATP6V0E2;SLC12A7;...
Glycine, serine and threonine metabolism -1.69 2.29e-2 31/40 (77.5%) PIPOX;CTH;SRR;...
Herpes simplex virus 1 infection -1.69 2.43e-2 165/498 (33.13%) HLA-DMB;CALR;IFNAR2;...
Allograft rejection -1.70 2.17e-2 32/38 (84.21%) HLA-E;HLA-DRB1;HLA-DPB1;...
Steroid biosynthesis -1.71 2.13e-2 19/20 (95%) LIPA;EBP;CYP24A1;...
Graft-versus-host disease -1.72 2.08e-2 32/42 (76.19%) KIR3DL1;CD80;KLRD1;...
Mismatch repair -1.72 2.24e-2 22/23 (95.65%) RFC2;RFC3;RFC4;...
Peroxisome -1.72 2.35e-2 72/82 (87.8%) PEX2;PEX16;EHHADH;...
Autoimmune thyroid disease -1.72 2.56e-2 46/53 (86.79%) TSHR;TG;CD80;...
Proximal tubule bicarbonate reclamation -1.72 2.82e-2 21/23 (91.3%) SLC4A4;ATP1B2;CA4;...
Fatty acid degradation -1.73 2.92e-2 40/43 (93.02%) ADH6;ECI1;ACADM;...
Metabolism of xenobiotics by cytochrome P450 -1.77 2.11e-2 49/77 (63.64%) GSTM1;CYP2B6;CYP3A4;...
Influenza A -1.80 1.34e-2 156/172 (90.7%) IFNAR2;CASP9;ICAM1;...
Pentose and glucuronate interconversions -1.83 1.25e-2 17/34 (50%) GUSB;DCXR;UGT2A3;...
Measles -1.84 1.50e-2 133/139 (95.68%) IFNAR2;CASP9;DDX58;...
Hepatitis C -1.92 2.35e-3 139/157 (88.54%) IFNAR2;CASP9;CLDN15;...
Glycolysis / Gluconeogenesis -1.93 3.13e-3 56/67 (83.58%) ADH7;HK2;MINPP1;...
DNA replication -2.06 0.00e+0 34/36 (94.44%) PRIM2;POLE2;DNA2;...
Antigen processing and presentation -2.07 0.00e+0 60/78 (76.92%) HLA-DMB;CALR;LGMN;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.04uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H