Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM6QHDJ)

Drug Name
Ornidazole Drug Info
Cross-matching ID
PubChem CID
28061
ChEBI ID
CHEMBL1449676
CAS Number
CAS 16773-42-5
TTD Drug ID
D0D0BE
INTEDE Drug ID
DR1204

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Hematopoietic cell lineage 1.84 3.82e-2 90/99 (90.91%) IL7R;TFRC;CD3D;...
DNA replication 1.79 4.97e-2 34/36 (94.44%) POLE2;PCNA;MCM3;...
Pyruvate metabolism -1.71 4.63e-2 41/47 (87.23%) ME1;MDH2;ME3;...
Pentose and glucuronate interconversions -1.72 4.27e-2 17/34 (50%) UGT2B17;UGDH;AKR1B1;...
Other glycan degradation -1.72 4.74e-2 13/18 (72.22%) MAN2B2;HEXA;NEU1;...
Citrate cycle (TCA cycle) -1.76 2.67e-2 30/30 (100%) IDH2;MDH2;PDHA1;...
Ovarian steroidogenesis -1.79 1.86e-2 41/51 (80.39%) CYP1B1;HSD17B7;INSR;...
Ether lipid metabolism -1.80 1.97e-2 32/49 (65.31%) GAL3ST1;PLA2G10;ENPP2;...
Tryptophan metabolism -1.82 1.90e-2 35/42 (83.33%) KYAT3;CYP1A2;CAT;...
Longevity regulating pathway -1.84 1.78e-2 90/151 (59.6%) SESN1;CAT;ATF2;...
Coronavirus disease -1.91 3.95e-3 215/232 (92.67%) RPS10;FOS;RPS15;...
Ascorbate and aldarate metabolism -1.96 5.92e-3 15/30 (50%) UGT2B17;UGDH;ALDH9A1;...
Ribosome -2.00 1.18e-2 113/158 (71.52%) RPS10;RPS15;RSL24D1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H