Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM6TJFU)

Drug Name
CINANSERIN Drug Info
Synonyms
CINANSERIN; Cinanserin [INN]; 1166-34-3; Cinanserine [INN-French]; Cinanserinum [INN-Latin]; UNII-KI6J9OY7A3; Cinanserina [INN-Spanish]; KI6J9OY7A3; CHEMBL18786; NCGC00024599-02; 2-Propenamide, N-(2-((3-(dimethylamino)propyl)thio)phenyl)-3-phenyl-; DSSTox_RID_81031; DSSTox_CID_25653; DSSTox_GSID_45653; Cinanserinum; Cinanserina; Cinanserine; CAS-1166-34-3; Cinanserin Monohydrochloride; Cinaserin; SQ 16167; SQ-16,167; SQ-10,643; AC1NUDS4; Biomol-NT_000092; 2'-((3-Dimethylaminopropyl)thio)cinnamanilide; SCHEMBL571561; BPBio1_001097
Cross-matching ID
PubChem CID
5475158
ChEBI ID
CHEMBL18786
CAS Number
CAS 1166-34-3
TTD Drug ID
D0B3WX

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Nucleotide excision repair 2.02 1.73e-2 40/47 (85.11%) RFC4;POLE2;RFC3;...
Graft-versus-host disease 1.99 8.66e-3 32/42 (76.19%) HLA-DPB1;HLA-DQB1;HLA-DPA1;...
DNA replication 1.99 8.66e-3 34/36 (94.44%) RFC4;MCM3;POLE2;...
Mismatch repair 1.96 6.50e-3 22/23 (95.65%) RFC4;RFC3;POLD3;...
Proteasome 1.84 1.56e-2 44/46 (95.65%) PSMD2;PSMB5;PSMC6;...
Systemic lupus erythematosus 1.77 2.31e-2 45/135 (33.33%) HLA-DPB1;C7;C1R;...
Allograft rejection 1.74 3.34e-2 32/38 (84.21%) HLA-DPB1;HLA-DQB1;HLA-DPA1;...
Focal adhesion -1.69 4.71e-2 180/201 (89.55%) FLNA;PAK2;GRB2;...
Nitrogen metabolism -1.70 4.72e-2 16/17 (94.12%) GLUL;CA12;GLUD2;...
Fructose and mannose metabolism -1.72 4.15e-2 30/33 (90.91%) PFKFB3;AKR1B10;PMM2;...
Pentose and glucuronate interconversions -1.75 3.41e-2 17/34 (50%) UGT2B17;AKR1A1;UGT2B4;...
Thyroid hormone synthesis -1.76 3.16e-2 66/75 (88%) TG;TTR;PRKCA;...
Glyoxylate and dicarboxylate metabolism -1.77 2.96e-2 23/30 (76.67%) HAO1;MMUT;HAO2;...
Ascorbate and aldarate metabolism -1.78 3.03e-2 15/30 (50%) UGT2B17;AKR1A1;UGT2B4;...
Adherens junction -1.80 2.33e-2 63/71 (88.73%) RAC1;SSX2IP;YES1;...
Vibrio cholerae infection -1.81 1.98e-2 44/50 (88%) ARF1;ATP6V0C;SEC61A1;...
Nicotine addiction -1.86 1.25e-2 32/40 (80%) GABRA1;GABRG2;SLC17A6;...
Protein digestion and absorption -1.90 4.76e-3 78/103 (75.73%) SLC7A7;CTRL;MEP1A;...
Mineral absorption -1.91 5.56e-3 48/60 (80%) SLC30A1;SLC39A4;ATP2B1;...
Retinol metabolism -1.91 6.67e-3 41/68 (60.29%) HSD17B6;LRAT;ADH1C;...
GABAergic synapse -1.93 8.34e-3 76/89 (85.39%) GLS;GPHN;GABRA1;...
Vitamin digestion and absorption -1.98 7.41e-3 17/24 (70.83%) TCN2;SLC5A6;LRAT;...
Arginine biosynthesis -2.05 5.56e-3 17/22 (77.27%) GLUL;OTC;ASL;...
Proximal tubule bicarbonate reclamation -2.09 0.00e+0 21/23 (91.3%) GLUD2;CA4;SLC4A4;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 10uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H, 24H