Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM6V13W)

Drug Name
PMID27336223-Compound-9 Drug Info
Cross-matching ID
PubChem CID
9952709
ChEBI ID
CHEMBL5277896
CAS Number
CAS 107430-66-0
TTD Drug ID
D0ZQ0X

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
IL-17 signaling pathway 2.28 0.00e+0 84/94 (89.36%) CCL2;CXCL8;CXCL1;...
TNF signaling pathway 2.21 0.00e+0 103/112 (91.96%) CCL2;CXCL1;CXCL2;...
NF-kappa B signaling pathway 2.21 0.00e+0 90/104 (86.54%) CXCL8;CXCL1;CXCL2;...
Viral protein interaction with cytokine and cytokine re... 2.13 2.46e-3 84/100 (84%) CCL2;CXCL8;CXCL1;...
Ferroptosis 2.06 3.93e-3 36/41 (87.8%) HMOX1;STEAP3;SLC7A11;...
Spliceosome 1.99 4.91e-3 101/150 (67.33%) HSPA6;LSM5;SRSF6;...
Retinol metabolism 1.93 5.62e-3 41/68 (60.29%) DHRS3;ALDH1A3;ADH1C;...
Legionellosis 1.90 4.91e-3 51/57 (89.47%) CXCL8;CXCL1;CXCL2;...
Ribosome biogenesis in eukaryotes 1.88 4.37e-3 52/108 (48.15%) NOP56;DKC1;NMD3;...
Protein processing in endoplasmic reticulum 1.84 4.91e-3 127/171 (74.27%) DDIT3;DNAJB1;HERPUD1;...
Rheumatoid arthritis 1.83 7.15e-3 78/93 (83.87%) CCL2;CXCL8;CXCL1;...
Cysteine and methionine metabolism 1.74 3.03e-2 43/50 (86%) PSAT1;CBS;PHGDH;...
Pertussis 1.73 3.02e-2 64/76 (84.21%) CXCL8;CXCL6;JUN;...
Lipid and atherosclerosis 1.72 2.88e-2 190/215 (88.37%) CCL2;CXCL8;DDIT3;...
Porphyrin and chlorophyll metabolism 1.71 3.14e-2 23/43 (53.49%) HMOX1;HMBS;FXN;...
Glutathione metabolism 1.71 3.07e-2 43/57 (75.44%) CHAC1;GPX2;PGD;...
Cytokine-cytokine receptor interaction 1.70 2.89e-2 246/295 (83.39%) CCL2;CXCL8;CXCL1;...
Linoleic acid metabolism 1.70 2.95e-2 21/29 (72.41%) PLA2G2A;PLAAT3;CYP1A2;...
NOD-like receptor signaling pathway 1.70 2.84e-2 145/181 (80.11%) CCL2;CXCL8;CXCL1;...
Arachidonic acid metabolism 1.70 2.70e-2 48/61 (78.69%) PLA2G2A;GPX2;PTGES;...
Pentose and glucuronate interconversions 1.70 2.71e-2 17/34 (50%) SORD;AKR1B1;UGDH;...
Toll-like receptor signaling pathway 1.67 3.44e-2 94/104 (90.38%) CXCL8;IKBKE;JUN;...
Cardiac muscle contraction -1.82 3.06e-2 64/87 (73.56%) ATP1A1;ASPH;CACNG4;...
Steroid biosynthesis -2.19 0.00e+0 19/20 (95%) CYP24A1;HSD17B7;FDFT1;...
Oxidative phosphorylation -2.24 0.00e+0 93/133 (69.92%) ATP6V1F;ATP5F1E;ATP5MC3;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 40uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 40uM 6H, 24H
Colon
Colon carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 TP53(-/-) CVCL_HD97 Homo sapiens 0.04uM - 10uM 24H
HCT 116 CVCL_0291 Homo sapiens 0.04uM - 10uM 24H
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CL-34 CVCL_1123 Homo sapiens 40uM 6H
HT-29 CVCL_0320 Homo sapiens 0.04uM - 40uM 6H, 24H
LoVo CVCL_0399 Homo sapiens 40uM 6H
MDST8 CVCL_1400 Homo sapiens 40uM 6H
NCI-H508 CVCL_1561 Homo sapiens 40uM 6H
SNU-1040 CVCL_5001 Homo sapiens 40uM 6H
SNU-C4 CVCL_5008 Homo sapiens 40uM 6H
SNU-C5 CVCL_5009 Homo sapiens 40uM 6H
SW480 CVCL_0546 Homo sapiens 40uM 6H
SW620 CVCL_0547 Homo sapiens 40uM 6H
SW948 CVCL_0550 Homo sapiens 40uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 40uM 6H
HCT 116 (Parent) CVCL_0291 Homo sapiens 0.04uM - 10uM 24H
HT115 CVCL_1294 Homo sapiens 40uM 6H
RKO CVCL_0504 Homo sapiens 40uM 6H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 40uM 6H
SNG-M CVCL_1707 Homo sapiens 40uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 40uM 6H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.04uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 40uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.04uM - 40uM 6H, 24H
DV-90 CVCL_1184 Homo sapiens 40uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 40uM 6H
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 40uM 6H
T3M-10 CVCL_1729 Homo sapiens 40uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC15 CVCL_1253 Homo sapiens 40uM 6H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 40uM 6H
HCC515 CVCL_5134 Homo sapiens 0.04uM - 40uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 40uM 6H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1694 CVCL_1495 Homo sapiens 40uM 6H
NCI-H1836 CVCL_1502 Homo sapiens 40uM 6H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 40uM 6H
OV7 CVCL_1623 Homo sapiens 40uM 6H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RMG-I CVCL_1663 Homo sapiens 40uM 6H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 40uM 6H
RMUG-S CVCL_1666 Homo sapiens 40uM 6H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 40uM 6H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NOMO-1 CVCL_1609 Homo sapiens 40uM 6H
PL-21 CVCL_2161 Homo sapiens 40uM 6H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.04uM - 40uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 40uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 40uM 6H, 24H
SK-MEL-1 CVCL_0523 Homo sapiens 40uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 40uM 6H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 40uM 6H