Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM6VFO1)

Drug Name
Pregnenolone Drug Info
Synonyms Pregnenolone (schizophrenia); Neurosteroid (schizophrenia), Neuroscience; Pregnenolone (schizophrenia), Neuroscience
Cross-matching ID
PubChem CID
8955
ChEBI ID
CHEMBL16581
CAS Number
CAS 145-13-1
TTD Drug ID
D0B4RU
INTEDE Drug ID
DR1336

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.36 0.00e+0 34/36 (94.44%) MCM3;MCM2;MCM4;...
Progesterone-mediated oocyte maturation 2.26 0.00e+0 75/100 (75%) GNAI1;CCNA2;ADCY1;...
Cell cycle 2.04 0.00e+0 110/124 (88.71%) CDC20;MCM3;SMC1A;...
Oocyte meiosis 2.00 0.00e+0 90/129 (69.77%) CDC20;SMC1A;ADCY1;...
Mismatch repair 1.94 2.40e-3 22/23 (95.65%) PCNA;RFC4;RPA1;...
Fanconi anemia pathway 1.90 4.00e-3 36/54 (66.67%) FANCI;RAD51;FANCG;...
One carbon pool by folate 1.90 3.42e-3 15/20 (75%) TYMS;DHFR;MTHFD1;...
Pyrimidine metabolism 1.81 1.35e-2 40/56 (71.43%) NT5E;TYMS;RRM2;...
Citrate cycle (TCA cycle) 1.80 1.33e-2 30/30 (100%) DLD;PCK1;CS;...
Base excision repair 1.75 2.04e-2 29/33 (87.88%) PARP2;POLE2;FEN1;...
Lysosome -1.75 3.39e-2 115/128 (89.84%) NAGLU;ATP6V0D1;GNS;...
Autophagy -1.77 3.41e-2 113/169 (66.86%) IGF1R;ATG16L1;DAPK3;...
Viral protein interaction with cytokine and cytokine re... -1.84 2.23e-2 84/100 (84%) CCL13;CCR7;CCR5;...
Mitophagy -1.95 8.13e-3 56/68 (82.35%) AMBRA1;RRAS2;BECN1;...
Legionellosis -1.96 8.13e-3 51/57 (89.47%) IL18;TLR5;EEF1A2;...
Steroid biosynthesis -2.39 0.00e+0 19/20 (95%) HSD17B7;FDFT1;CYP51A1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 15uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Fibroblast
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
FIBRNPC CVCL_UK07 Homo sapiens 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.66uM - 20uM 3H, 6H, 24H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 10uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H