Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM6VOWQ)

• Drug Name: Fomepizole Drug Info
• Synonyms: Antizol; Fomepizol; Fomepizolum; Orphan brand of fomepizole; Paladin brand of fomepizole; M0774; Antizol (TN); Fomepizol [INN-Spanish]; Fomepizole [USAN:INN]; Fomepizolum [INN-Latin]; S14-0570; Fomepizole (USAN/INN); 4-Methyl-1H-pyrazole; 4-Methylpyrazol; 4-Methylpyrazole; 4-methylpyrazole monohydrochloride
• Therapeutic Class: Antidotes
• Cross-matching ID:
  PubChem CID: 3406
  ChEBI ID: CHEMBL5141
  CAS Number: CAS 7554-65-6
  TTD Drug ID: D02NJA
  INTEDE Drug ID: DR0743

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
DNA replication	2.15	0.00e+0	34/36 (94.44%)	MCM5;MCM2;POLE;...
Mismatch repair	2.07	0.00e+0	22/23 (95.65%)	MSH6;RFC2;POLD3;...
Base excision repair	1.98	0.00e+0	29/33 (87.88%)	POLE;FEN1;APEX1;...
Progesterone-mediated oocyte maturation	1.94	1.14e-2	75/100 (75%)	PIK3CD;CCNB1;BUB1;...
Pentose and glucuronate interconversions	1.91	1.37e-2	17/34 (50%)	UGT2B17;UGP2;UGT2B15;...
Glyoxylate and dicarboxylate metabolism	1.88	2.09e-2	23/30 (76.67%)	DLD;ACAT2;HYI;...
Glycine, serine and threonine metabolism	1.83	3.26e-2	31/40 (77.5%)	DLD;PGAM1;GNMT;...
Valine, leucine and isoleucine degradation	1.80	3.28e-2	42/48 (87.5%)	DLD;ALDH2;AACS;...
Cell cycle	1.78	3.68e-2	110/124 (88.71%)	CDC20;ESPL1;CHEK2;...
Oocyte meiosis	1.74	4.00e-2	90/129 (69.77%)	CDC20;ESPL1;PPP3CA;...
Ascorbate and aldarate metabolism	1.74	3.74e-2	15/30 (50%)	UGT2B17;ALDH2;UGT2B15;...
Fanconi anemia pathway	1.67	4.87e-2	36/54 (66.67%)	FANCI;FANCA;BRCA1;...
Complement and coagulation cascades	-1.97	0.00e+0	76/85 (89.41%)	C8B;PROCR;PLAU;...
ECM-receptor interaction	-2.13	0.00e+0	80/88 (90.91%)	COL2A1;VWF;THBS3;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	6H, 24H	Hide ▲
MDA-MB-231	CVCL_0062	Homo sapiens	0.01uM - 10uM	24H	Hide ▲

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEK293	CVCL_0045	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Peripheral blood

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	0.04uM - 10uM	24H	Show ▼

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.04uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	24H	Show ▼