Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM6X0PZ)

Drug Name
SB222200 Drug Info
Synonyms
S 5192; SB 222200; SB-222200; N-(alpha-ethylbenzyl)-3-methyl-2-phenylquinoline-4-carboxamide; (S)-3-Methyl-2-phenyl-N-(1-phenylpropyl)-4-quinolinecarboxamide; 3-methyl-2-phenyl-N-[(1S)-1-phenylpropyl]quinoline-4-carboxamide
Cross-matching ID
PubChem CID
6604009
ChEBI ID
CHEMBL10284
CAS Number
CAS 174635-69-9
TTD Drug ID
D00VPT

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 1.86 3.77e-2 34/36 (94.44%) POLE2;PCNA;RFC4;...
Cell adhesion molecules 1.78 4.72e-2 118/148 (79.73%) CD2;CD8A;CD58;...
Regulation of lipolysis in adipocytes -1.74 4.20e-2 52/55 (94.55%) ADCY8;ABHD5;ADRB2;...
Nitrogen metabolism -1.75 4.20e-2 16/17 (94.12%) CA6;CA4;GLUL;...
Aldosterone-regulated sodium reabsorption -1.77 4.20e-2 34/37 (91.89%) PDPK1;KCNJ1;PRKCA;...
Cholesterol metabolism -1.77 4.46e-2 44/50 (88%) APOC2;ABCA1;STAR;...
Complement and coagulation cascades -1.81 2.80e-2 76/85 (89.41%) CD59;PLG;CR2;...
Proximal tubule bicarbonate reclamation -1.84 4.20e-2 21/23 (91.3%) ATP1A2;PCK2;ATP1A1;...
Renin-angiotensin system -1.95 1.05e-2 20/23 (86.96%) CPA3;PREP;KLK1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H