Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM6XFHS)

• Drug Name: SPI-1005 Drug Info
• Synonyms: Ebselen [INN]; Ebselene; Ebselene [French]; Ebseleno; Ebseleno [Spanish]; Ebselenum; Ebselenum [Latin]; Harmokisane; PZ 51; PZ-51; PZ51; RP 60931; SPI-1005; SPI-3005; 2-Phenyl-1,2-benzisoselenazol-3(2H)-one; 2-Phenyl-1,2-benzisoselenazolin-3-one; 2-phenyl-1,2-benzoisoselenazol-3(2H)-one; 2-phenyl-1,2-benzoselenazol-3-one; DR 3305; DR-3305; E 3520
• Therapeutic Class: Fibrinolytic Agents
• Cross-matching ID:
  PubChem CID: 3194
  ChEBI ID: CHEMBL51085
  CAS Number: CAS 60940-34-3
  TTD Drug ID: D0B1FE

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Fatty acid degradation	-1.63	3.60e-2	40/43 (93.02%)	ACOX3;ACADL;ALDH7A1;...
Phagosome	-1.68	2.31e-2	118/152 (77.63%)	DYNC2H1;DYNC1LI2;DYNC1I2;...
Glyoxylate and dicarboxylate metabolism	-1.68	2.38e-2	23/30 (76.67%)	AGXT;HAO1;AMT;...
Arginine biosynthesis	-1.71	1.80e-2	17/22 (77.27%)	OTC;ARG2;GLUD2;...
Nicotinate and nicotinamide metabolism	-1.72	1.80e-2	25/35 (71.43%)	QPRT;SIRT5;NMRK1;...
Mitophagy	-1.74	1.59e-2	56/68 (82.35%)	MFN1;JUN;CSNK2B;...
Leishmaniasis	-1.77	1.07e-2	67/77 (87.01%)	EEF1A2;TAB1;HLA-DOB;...
Primary bile acid biosynthesis	-1.77	1.14e-2	15/17 (88.24%)	AKR1D1;CYP7A1;BAAT;...
Synthesis and degradation of ketone bodies	-1.79	1.16e-2	9/10 (90%)	HMGCL;ACAT1;BDH2;...
Alanine, aspartate and glutamate metabolism	-1.79	1.25e-2	27/37 (72.97%)	GLUD2;GAD1;CPS1;...
Propanoate metabolism	-1.79	1.20e-2	30/34 (88.24%)	ACACA;BCKDHB;ALDH6A1;...
Other glycan degradation	-1.86	4.90e-3	13/18 (72.22%)	AGA;MANBA;NEU1;...
Porphyrin and chlorophyll metabolism	-1.89	1.80e-3	23/43 (53.49%)	UGT2B28;CPOX;HMBS;...
Peroxisome	-1.90	2.00e-3	72/82 (87.8%)	SOD1;CROT;PEX12;...
Metabolism of xenobiotics by cytochrome P450	-1.95	2.25e-3	49/77 (63.64%)	ADH6;ADH1C;MGST3;...
Linoleic acid metabolism	-1.96	2.57e-3	21/29 (72.41%)	CYP1A2;CYP2E1;CYP2J2;...
Drug metabolism	-2.00	1.50e-3	78/151 (51.66%)	ADH6;ADH1C;CDA;...
Complement and coagulation cascades	-2.02	1.80e-3	76/85 (89.41%)	A2M;CD55;SERPINC1;...
Valine, leucine and isoleucine degradation	-2.02	2.25e-3	42/48 (87.5%)	ALDH7A1;ACADSB;HMGCS1;...
Butanoate metabolism	-2.08	0.00e+0	23/28 (82.14%)	HMGCS1;L2HGDH;HADHA;...
Retinol metabolism	-2.18	0.00e+0	41/68 (60.29%)	RDH16;ADH6;ADH1C;...
Glycine, serine and threonine metabolism	-2.26	0.00e+0	31/40 (77.5%)	SRR;AGXT;GAMT;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	10uM	6H	Hide ▲

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	6H, 24H	Hide ▲

Fibrocystic breast disease

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A (Parent)	CVCL_0598	Homo sapiens	1.11uM - 10uM	3H, 6H, 12H, 24H	Show ▼

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	3H, 24H	Show ▼

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.04uM - 10uM	6H, 24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	10uM	6H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼