Details of the Drug Pharmacogenomic Perturbation Atlas

Aphidicolin Drug Info

bis(hydroxymethyl)-dimethyl-[ ]diol; AC1LA8KN; 8,11a-Methano-11aH-cyclohepta[a]naphthalene-4,9-dimethanol, tetradecahydro-3,9-dihydroxy-4,11b-dimethyl-, (3R,4R,9R,11bS)-

Cross-matching ID

PubChem CID

457964

ChEBI ID

CHEMBL29711

CAS Number

CAS 38966-21-1

TTD Drug ID

D05RQB

General Information of Drug (ID: DM71C6D)

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
p53 signaling pathway	2.29	0.00e+0	63/73 (86.3%)	CDKN1A;RRM2;SFN;...
Glutathione metabolism	2.18	0.00e+0	43/57 (75.44%)	RRM2;GPX3;GSTM3;...
Metabolism of xenobiotics by cytochrome P450	2.15	0.00e+0	49/77 (63.64%)	GSTM3;GSTP1;AKR7A2;...
DNA replication	2.03	2.97e-3	34/36 (94.44%)	POLD4;RFC5;LIG1;...
Mismatch repair	2.00	2.37e-3	22/23 (95.65%)	POLD4;RFC5;LIG1;...
Drug metabolism	1.97	1.98e-3	78/151 (51.66%)	RRM2;GSTM3;UPP1;...
Mineral absorption	1.97	1.69e-3	48/60 (80%)	MT1F;MT2A;MT1H;...
Primary immunodeficiency	1.94	4.45e-3	33/38 (86.84%)	TAP1;CD40;ADA;...
Cardiac muscle contraction	1.86	1.05e-2	64/87 (73.56%)	TNNC1;TPM2;MYL2;...
Sulfur metabolism	1.82	1.66e-2	9/10 (90%)	TST;ETHE1;PAPSS2;...
Fructose and mannose metabolism	1.79	2.48e-2	30/33 (90.91%)	AKR1B10;PFKL;TIGAR;...
Viral myocarditis	1.77	2.97e-2	53/60 (88.33%)	CXADR;CD40;HLA-F;...
Influenza A	1.75	2.83e-2	156/172 (90.7%)	MX1;OAS1;TNFSF10;...
Measles	1.71	4.58e-2	133/139 (95.68%)	MX1;OAS1;OAS3;...
Small cell lung cancer	1.71	4.35e-2	90/92 (97.83%)	CDKN1A;DDB2;LAMA5;...
Homologous recombination	1.68	4.95e-2	35/41 (85.37%)	POLD4;BRCA1;RPA3;...
Protein export	-1.70	3.71e-2	17/23 (73.91%)	SEC61B;SRP9;SEC11A;...
Aminoacyl-tRNA biosynthesis	-1.88	5.40e-3	15/66 (22.73%)	WARS2;FARSA;GATC;...
RNA transport	-2.08	0.00e+0	128/186 (68.82%)	XPO1;NUP93;RNPS1;...
mRNA surveillance pathway	-2.14	0.00e+0	71/98 (72.45%)	PABPC1;CSTF2;PPP2R5C;...
Ribosome biogenesis in eukaryotes	-2.43	0.00e+0	52/108 (48.15%)	IMP3;NXF1;GNL2;...
Spliceosome	-2.48	0.00e+0	101/150 (67.33%)	SRSF6;PRPF40A;PRPF38B;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.01uM - 10uM	24H

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	24H

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	24H

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEK293	CVCL_0045	Homo sapiens	0.01uM - 10uM	24H

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	24H

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H

Peripheral blood

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	0.01uM - 2.22uM	24H

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.01uM - 10uM	24H

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	24H

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	24H