Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM71WQT)

Drug Name
AR-C133057XX Drug Info
Synonyms
CHEMBL114500; 4-({4-[(4-Methoxypyridin-2-Yl)amino]piperidin-1-Yl}carbonyl)benzonitrile; 4-[4-[(4-Methoxypyridin-2-yl)amino]piperidine-1-carbonyl]benzonitrile; 4-{4-[(4-methoxypyridin-2-yl)amino]piperidine-1-carbonyl}benzonitrile; AR-C133057XX; SCHEMBL7824352; CHEBI:95013; BDBM50148167; DB07002; BRD-K40892394-001-01-9; 4-(4-(4-methoxypyridin-2-ylamino)piperidine-1-carbonyl)benzonitrile; 4-[4-(4-Methoxy-pyridin-2-ylamino)-piperidine-1-carbonyl]-benzonitrile
Cross-matching ID
PubChem CID
9797857
ChEBI ID
CHEMBL95013
CAS Number
CAS 268730-08-1
TTD Drug ID
D0OW8M

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Cell cycle 2.53 0.00e+0 110/124 (88.71%) PLK1;CDC20;CCNA2;...
Progesterone-mediated oocyte maturation 2.22 0.00e+0 75/100 (75%) PLK1;CCNA2;AURKA;...
Oocyte meiosis 2.22 0.00e+0 90/129 (69.77%) PLK1;CDC20;AURKA;...
DNA replication 2.16 0.00e+0 34/36 (94.44%) POLE2;SSBP1;MCM4;...
Spliceosome 2.02 0.00e+0 101/150 (67.33%) LSM6;HSPA8;HNRNPK;...
Cardiac muscle contraction 2.00 1.89e-3 64/87 (73.56%) COX7B;TNNC1;MYL4;...
p53 signaling pathway 1.98 1.62e-3 63/73 (86.3%) THBS1;CCNB2;CYCS;...
Fanconi anemia pathway 1.90 7.09e-3 36/54 (66.67%) BRCA1;REV1;FANCI;...
Biosynthesis of unsaturated fatty acids 1.85 8.82e-3 21/27 (77.78%) SCD5;ELOVL2;HACD3;...
RNA transport 1.83 9.07e-3 128/186 (68.82%) NUP93;EIF5B;EIF3A;...
Homologous recombination 1.76 2.37e-2 35/41 (85.37%) SSBP1;BARD1;BRCA1;...
Arrhythmogenic right ventricular cardiomyopathy 1.71 3.97e-2 70/77 (90.91%) ITGA6;ITGB4;TCF7;...
Cellular senescence 1.69 4.27e-2 139/156 (89.1%) CCNA2;TGFBR2;CCNB2;...
Dilated cardiomyopathy 1.67 4.76e-2 86/96 (89.58%) ITGA6;ITGB4;IGF1;...
Aldosterone-regulated sodium reabsorption 1.66 4.89e-2 34/37 (91.89%) IGF1;ATP1A1;KRAS;...
Melanogenesis 1.66 4.60e-2 74/101 (73.27%) GNAQ;TCF7;FZD1;...
Pyrimidine metabolism 1.66 4.60e-2 40/56 (71.43%) RRM2;RRM1;CTPS1;...
Retinol metabolism -1.58 4.79e-2 41/68 (60.29%) RDH11;DHRS3;RETSAT;...
Glycerolipid metabolism -1.58 4.93e-2 44/61 (72.13%) PLPP3;GK;MGLL;...
ABC transporters -1.58 4.78e-2 37/45 (82.22%) DEFB1;ABCA1;ABCA8;...
Riboflavin metabolism -1.59 4.97e-2 7/8 (87.5%) ACP5;BLVRB;ENPP1;...
Selenocompound metabolism -1.59 4.81e-2 11/17 (64.71%) SEPHS2;PAPSS1;CTH;...
Ether lipid metabolism -1.60 4.60e-2 32/49 (65.31%) PLA2G2D;PLA2G6;GAL3ST1;...
Glycolysis / Gluconeogenesis -1.60 4.81e-2 56/67 (83.58%) DLD;BPGM;ADH7;...
TNF signaling pathway -1.60 4.87e-2 103/112 (91.96%) MMP9;NOD2;TNFAIP3;...
Pentose phosphate pathway -1.61 4.67e-2 25/30 (83.33%) PRPS2;PFKL;PFKM;...
Autophagy -1.61 4.83e-2 113/169 (66.86%) INS;RAB7A;ATG101;...
Arachidonic acid metabolism -1.62 4.31e-2 48/61 (78.69%) ALOX15;PLA2G2D;PLA2G6;...
Alanine, aspartate and glutamate metabolism -1.63 4.25e-2 27/37 (72.97%) GLUL;ABAT;ASPA;...
Viral protein interaction with cytokine and cytokine re... -1.65 3.86e-2 84/100 (84%) CXCL3;IL18RAP;CCL19;...
Porphyrin and chlorophyll metabolism -1.70 2.53e-2 23/43 (53.49%) BLVRB;PPOX;FECH;...
Pentose and glucuronate interconversions -1.71 2.46e-2 17/34 (50%) AKR1B10;UGT2B17;AKR1B1;...
Sulfur metabolism -1.72 2.31e-2 9/10 (90%) SUOX;TST;MPST;...
Phenylalanine metabolism -1.74 1.84e-2 14/17 (82.35%) MAOB;ALDH3A1;MAOA
Glycine, serine and threonine metabolism -1.79 1.04e-2 31/40 (77.5%) DLD;BPGM;PSPH;...
Amino sugar and nucleotide sugar metabolism -1.81 5.29e-3 38/48 (79.17%) GMDS;CYB5R2;NPL;...
Ascorbate and aldarate metabolism -1.81 5.88e-3 15/30 (50%) UGT2B17;AKR1A1;ALDH2;...
Tryptophan metabolism -1.86 4.41e-3 35/42 (83.33%) DLD;ALDH8A1;HADHA;...
Metabolism of xenobiotics by cytochrome P450 -1.91 2.52e-3 49/77 (63.64%) GSTM3;CYP2A13;ADH7;...
Arginine and proline metabolism -1.92 1.47e-3 39/50 (78%) PYCR1;CKB;AOC1;...
Protein processing in endoplasmic reticulum -1.92 1.76e-3 127/171 (74.27%) SEC24B;P4HB;EDEM1;...
Mineral absorption -1.93 2.20e-3 48/60 (80%) MT1X;SLC31A1;MT1E;...
Mitophagy -2.02 0.00e+0 56/68 (82.35%) CSNK2A2;OPTN;ULK1;...
Ferroptosis -2.03 0.00e+0 36/41 (87.8%) SLC3A2;ACSL1;SLC39A8;...
Histidine metabolism -2.05 0.00e+0 16/22 (72.73%) ASPA;ALDH9A1;AOC1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 12uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 12uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CL-34 CVCL_1123 Homo sapiens 12uM 6H
HT-29 CVCL_0320 Homo sapiens 12uM 6H, 24H
LoVo CVCL_0399 Homo sapiens 12uM 6H
MDST8 CVCL_1400 Homo sapiens 12uM 6H
NCI-H508 CVCL_1561 Homo sapiens 12uM 6H
SNU-1040 CVCL_5001 Homo sapiens 12uM 6H
SNU-C4 CVCL_5008 Homo sapiens 12uM 6H
SNU-C5 CVCL_5009 Homo sapiens 12uM 6H
SW480 CVCL_0546 Homo sapiens 12uM 6H
SW620 CVCL_0547 Homo sapiens 12uM 6H
SW948 CVCL_0550 Homo sapiens 12uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 12uM 6H
HT115 CVCL_1294 Homo sapiens 12uM 6H
RKO CVCL_0504 Homo sapiens 12uM 6H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 12uM 6H
SNG-M CVCL_1707 Homo sapiens 12uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 12uM 6H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 12uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 12uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 12uM 6H, 24H
DV-90 CVCL_1184 Homo sapiens 12uM 6H
SK-LU-1 CVCL_0624 Homo sapiens 12uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 12uM 6H
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 12uM 6H
T3M-10 CVCL_1729 Homo sapiens 12uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC15 CVCL_1253 Homo sapiens 12uM 6H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 12uM 6H
HCC515 CVCL_5134 Homo sapiens 12uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 12uM 6H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1694 CVCL_1495 Homo sapiens 12uM 6H
NCI-H1836 CVCL_1502 Homo sapiens 12uM 6H
Lymph node
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WSU-DLCL2 CVCL_1787 Homo sapiens 12uM 6H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 12uM 6H
OV7 CVCL_1623 Homo sapiens 12uM 6H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RMG-I CVCL_1663 Homo sapiens 12uM 6H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 12uM 6H
RMUG-S CVCL_1666 Homo sapiens 12uM 6H
Ovarian undifferentiated carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TYK-nu CVCL_1774 Homo sapiens 12uM 6H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 12uM 6H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NOMO-1 CVCL_1609 Homo sapiens 12uM 6H
PL-21 CVCL_2161 Homo sapiens 12uM 6H
SKM-1 CVCL_0010 Homo sapiens 12uM 6H
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 12uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 12uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 12uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 12uM 6H, 24H
SK-MEL-1 CVCL_0523 Homo sapiens 12uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 12uM 6H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 12uM 6H