Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM7245Q)

Drug Name
Ioxaglate Drug Info
Synonyms
ioxaglic acid; Ioxaglate; Hexabrix 160; 59017-64-0; Acido ioxaglico; Acide ioxaglique; Acidum ioxaglicum; UNII-Z40X7EI2AF; P 286 (Contrast medium); Acido ioxaglico [INN-Spanish]; Acidum ioxaglicum [INN-Latin]; Acide ioxaglique [INN-French]; EINECS 261-560-1; Z40X7EI2AF; N-(2-Hydroxyethyl)-2,4,6-triiodo-5-(2-(2,4,6-triiodo-3-(N-methylacetamido)-5-(methylcarbamoyl)benzamido)acetamido)isophthalamic acid; P 286; CHEBI:31718
Cross-matching ID
PubChem CID
3742
ChEBI ID
CHEMBL31718
CAS Number
CAS 59017-64-0
TTD Drug ID
D0X7IT

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Cardiac muscle contraction 2.05 0.00e+0 64/87 (73.56%) ACTC1;TNNC1;ATP1B3;...
Oxidative phosphorylation 1.94 0.00e+0 93/133 (69.92%) ATP5F1C;ATP5PF;NDUFB5;...
Parkinson disease 1.87 1.03e-2 176/249 (70.68%) ATP5F1C;UCHL1;NFE2L2;...
Citrate cycle (TCA cycle) 1.76 4.11e-2 30/30 (100%) DLD;SUCLG1;IDH3A;...
Proteasome 1.75 3.70e-2 44/46 (95.65%) PSMA3;PSMB3;PSMC6;...
Huntington disease 1.74 4.28e-2 233/306 (76.14%) ATP5F1C;POLR2G;ATP5PF;...
Malaria -1.68 4.54e-2 44/50 (88%) HGF;IL6;THBS2;...
Synthesis and degradation of ketone bodies -1.79 8.52e-3 9/10 (90%) HMGCS1;HMGCS2;ACAT2
Vitamin digestion and absorption -1.85 1.39e-3 17/24 (70.83%) CUBN;LRAT;APOB;...
PPAR signaling pathway -1.94 0.00e+0 66/74 (89.19%) ACSBG1;CPT2;PCK1;...
Other glycan degradation -1.95 0.00e+0 13/18 (72.22%) MAN2C1;MAN2B2;HEXA;...
Butanoate metabolism -1.97 0.00e+0 23/28 (82.14%) ECHS1;GAD1;BDH2;...
Steroid biosynthesis -2.00 0.00e+0 19/20 (95%) SOAT1;EBP;NSDHL;...
Complement and coagulation cascades -2.08 0.00e+0 76/85 (89.41%) KNG1;F2;CPB2;...
NF-kappa B signaling pathway -2.15 0.00e+0 90/104 (86.54%) CFLAR;NFKBIA;BCL2;...
×

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H