Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM72JXH)

Drug Name
Losartan Drug Info
Synonyms
Cozaar; Cozaar (TN); DUP 89; DuP 753; DuP-753; Hyzaar; JMS50MPO89; LOSARTAN POTASSIUM; Lortaan; Losartan (INN); 114798-26-4; C22H23ClN6O; CHEBI:6541; CL23623; Losartan [INN:BAN]; Losartan monopotassium salt; Losartic; Losartic (TN); MK-954; MK954; UNII-JMS50MPO89; [3H]losartan
Therapeutic ClassAntihypertensive Agents
Cross-matching ID
PubChem CID
3961
ChEBI ID
CHEMBL191
CAS Number
CAS 114798-26-4
TTD Drug ID
D0DD0K
VARIDT Drug ID
DR00429
INTEDE Drug ID
DR0984
ACDINA Drug ID
D00153

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.54 0.00e+0 34/36 (94.44%) RFC3;POLE2;POLA2;...
Spliceosome 2.11 0.00e+0 101/150 (67.33%) SRSF1;SRSF7;LSM6;...
Cell cycle 2.09 0.00e+0 110/124 (88.71%) CCNA2;MAD2L1;CDK1;...
Nucleotide excision repair 2.05 0.00e+0 40/47 (85.11%) RFC3;POLE2;RFC5;...
Pyrimidine metabolism 2.01 0.00e+0 40/56 (71.43%) RRM2;RRM1;DPYD;...
Homologous recombination 2.01 0.00e+0 35/41 (85.37%) RAD54B;RAD51C;BRCA1;...
Mismatch repair 1.99 8.60e-4 22/23 (95.65%) RFC3;RFC5;POLD2;...
RNA transport 1.89 3.01e-3 128/186 (68.82%) NUP37;XPO1;NUP50;...
Asthma 1.89 2.67e-3 25/31 (80.65%) CD40;HLA-DQB1;HLA-DPA1;...
Aminoacyl-tRNA biosynthesis 1.84 5.41e-3 15/66 (22.73%) IARS2;QRSL1;DARS2;...
Ribosome biogenesis in eukaryotes 1.83 5.47e-3 52/108 (48.15%) NAT10;XPO1;GAR1;...
Ribosome 1.81 5.52e-3 113/158 (71.52%) MRPL12;MRPS12;MRPL20;...
Proteasome 1.81 5.09e-3 44/46 (95.65%) PSMA1;PSMC3;PSMC6;...
Fanconi anemia pathway 1.78 8.17e-3 36/54 (66.67%) USP1;RAD51C;ATR;...
Systemic lupus erythematosus 1.71 1.60e-2 45/135 (33.33%) C7;CD40;HLA-DQB1;...
Non-homologous end-joining 1.64 3.27e-2 11/13 (84.62%) FEN1;MRE11;DNTT;...
Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 1.62 3.82e-2 20/26 (76.92%) PIGF;GPAA1;DPM2;...
Base excision repair 1.60 4.11e-2 29/33 (87.88%) POLE2;FEN1;POLD2;...
Intestinal immune network for IgA production 1.60 4.27e-2 38/48 (79.17%) CD40;HLA-DQB1;HLA-DPA1;...
Protein export 1.59 4.18e-2 17/23 (73.91%) SRP9;SRPRB;SPCS1;...
Neurotrophin signaling pathway -1.74 4.36e-2 107/119 (89.92%) TRAF6;SHC1;PRDM4;...
Ferroptosis -1.76 4.55e-2 36/41 (87.8%) TF;PCBP2;SLC39A8;...
GnRH signaling pathway -1.77 4.60e-2 80/93 (86.02%) MAP2K2;GNA11;GRB2;...
Sulfur metabolism -1.78 4.90e-2 9/10 (90%) TST;SQOR;PAPSS2;...
Mineral absorption -1.81 4.48e-2 48/60 (80%) TRPV6;MT1H;SLC5A1;...
Lysosome -1.82 4.55e-2 115/128 (89.84%) CD68;LAPTM4A;ENTPD4;...
Parathyroid hormone synthesis, secretion and action -1.91 4.20e-2 98/106 (92.45%) RXRB;GNAQ;MMP15;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 150uM 6H
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 150uM 6H, 24H, 48H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CL-34 CVCL_1123 Homo sapiens 150uM 6H
HT-29 CVCL_0320 Homo sapiens 0.01uM - 150uM 6H, 24H
LoVo CVCL_0399 Homo sapiens 150uM 6H
MDST8 CVCL_1400 Homo sapiens 150uM 6H
NCI-H508 CVCL_1561 Homo sapiens 150uM 6H
SNU-1040 CVCL_5001 Homo sapiens 150uM 6H
SNU-C4 CVCL_5008 Homo sapiens 150uM 6H
SNU-C5 CVCL_5009 Homo sapiens 150uM 6H
SW480 CVCL_0546 Homo sapiens 150uM 6H
SW620 CVCL_0547 Homo sapiens 150uM 6H
SW948 CVCL_0550 Homo sapiens 150uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 150uM 6H
HT115 CVCL_1294 Homo sapiens 150uM 6H
RKO CVCL_0504 Homo sapiens 150uM 6H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 150uM 6H
SNG-M CVCL_1707 Homo sapiens 150uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 150uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 150uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM - 150uM 6H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 6.66uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 150uM 6H, 24H, 48H
DV-90 CVCL_1184 Homo sapiens 150uM 6H
SK-LU-1 CVCL_0624 Homo sapiens 150uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 150uM 6H
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 150uM 6H
T3M-10 CVCL_1729 Homo sapiens 150uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC15 CVCL_1253 Homo sapiens 150uM 6H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 150uM 6H
HCC515 CVCL_5134 Homo sapiens 10uM - 150uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 150uM 6H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1694 CVCL_1495 Homo sapiens 150uM 6H
NCI-H1836 CVCL_1502 Homo sapiens 150uM 6H
Lymph node
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WSU-DLCL2 CVCL_1787 Homo sapiens 150uM 6H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 150uM 6H
OV7 CVCL_1623 Homo sapiens 150uM 6H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RMG-I CVCL_1663 Homo sapiens 150uM 6H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 150uM 6H
RMUG-S CVCL_1666 Homo sapiens 150uM 6H
Ovarian undifferentiated carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TYK-nu CVCL_1774 Homo sapiens 150uM 6H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 150uM 6H, 24H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NOMO-1 CVCL_1609 Homo sapiens 150uM 6H
PL-21 CVCL_2161 Homo sapiens 150uM 6H
SKM-1 CVCL_0010 Homo sapiens 150uM 6H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 150uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 150uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM - 150uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 150uM 6H, 24H
SK-MEL-1 CVCL_0523 Homo sapiens 150uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 150uM 6H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 150uM 6H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 2.22uM 24H