Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM7B650)

Drug Name
RG-2833 Drug Info
Synonyms RG-FA; HDAC-1 inhibtors (Friedreich ataxia), RepliGen
Cross-matching ID
PubChem CID
56654642
ChEBI ID
CHEMBL3970532
CAS Number
CAS 1215493-56-3
TTD Drug ID
D0GE5B

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Complement and coagulation cascades 2.42 0.00e+0 76/85 (89.41%) TFPI;SERPING1;C1S;...
Mineral absorption 2.33 0.00e+0 48/60 (80%) MT1F;MT1X;MT1G;...
Steroid biosynthesis 1.92 1.10e-2 19/20 (95%) MSMO1;SC5D;TM7SF2;...
PPAR signaling pathway 1.91 1.03e-2 66/74 (89.19%) SCD;PLIN2;HMGCS1;...
Ascorbate and aldarate metabolism 1.88 1.15e-2 15/30 (50%) ALDH3A2;ALDH7A1;ALDH2;...
Biosynthesis of unsaturated fatty acids 1.80 1.78e-2 21/27 (77.78%) SCD;ELOVL5;FADS1;...
Arachidonic acid metabolism 1.76 2.23e-2 48/61 (78.69%) GPX3;ALOX5;PLAAT3;...
Metabolism of xenobiotics by cytochrome P450 1.74 2.98e-2 49/77 (63.64%) GSTM3;GSTA4;CYP1B1;...
Retinol metabolism 1.73 2.93e-2 41/68 (60.29%) ALDH1A3;CYP26B1;AOX1;...
Butanoate metabolism 1.73 2.72e-2 23/28 (82.14%) HMGCS1;ABAT;BDH2;...
Histidine metabolism 1.71 2.84e-2 16/22 (72.73%) ALDH3A2;MAOB;MAOA;...
Tryptophan metabolism 1.70 2.88e-2 35/42 (83.33%) ALDH3A2;KMO;MAOB;...
Steroid hormone biosynthesis 1.69 3.04e-2 43/61 (70.49%) CYP1B1;AKR1C2;HSD11B1;...
Pentose and glucuronate interconversions 1.66 4.06e-2 17/34 (50%) SORD;AKR1B1;AKR1B10;...
Glutathione metabolism 1.64 4.83e-2 43/57 (75.44%) GPX3;GSTM3;GSTA4;...
Synthesis and degradation of ketone bodies 1.63 4.68e-2 9/10 (90%) HMGCS1;BDH2
Spliceosome -1.95 1.31e-2 101/150 (67.33%) CRNKL1;TCERG1;PPIE;...
Ribosome biogenesis in eukaryotes -1.96 2.61e-2 52/108 (48.15%) NXT1;GNL2;POP4;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 2.22uM 24H