Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM7BA57)

Drug Name
Alizapride Drug Info
Synonyms HY-A0125A
Cross-matching ID
PubChem CID
135413504
ChEBI ID
CHEMBL94316
CAS Number
CAS 59338-93-1
TTD Drug ID
D06GJT

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Oxidative phosphorylation 2.14 0.00e+0 93/133 (69.92%) COX7B;NDUFB5;COX7A2;...
Ribosome 2.09 0.00e+0 113/158 (71.52%) RPL36;RPS26;RPL26L1;...
IL-17 signaling pathway 2.03 2.38e-3 84/94 (89.36%) CXCL8;CXCL2;CXCL1;...
Huntington disease 1.86 7.13e-3 233/306 (76.14%) BAX;COX7B;NDUFB5;...
Parkinson disease 1.86 7.13e-3 176/249 (70.68%) DAXX;BAX;COX7B;...
Amyotrophic lateral sclerosis 1.85 5.94e-3 267/364 (73.35%) DAXX;BAX;COX7B;...
Protein export 1.82 1.02e-2 17/23 (73.91%) SEC61G;SPCS1;SEC61B;...
Rheumatoid arthritis 1.81 8.91e-3 78/93 (83.87%) CXCL8;CXCL2;CXCL1;...
Epithelial cell signaling in Helicobacter pylori infect... 1.80 9.50e-3 62/70 (88.57%) CXCL8;CXCL2;CDC42;...
Viral protein interaction with cytokine and cytokine re... 1.79 9.98e-3 84/100 (84%) CXCL8;CXCL2;CXCL1;...
Prion disease 1.78 9.72e-3 209/273 (76.56%) BAX;COX7B;NDUFB5;...
TNF signaling pathway 1.75 1.31e-2 103/112 (91.96%) CXCL2;CXCL1;CXCL6;...
Thermogenesis 1.75 1.26e-2 173/232 (74.57%) COX7B;NDUFB5;COX7A2;...
Thiamine metabolism 1.75 1.27e-2 12/15 (80%) AK4;TPK1;ACP1;...
Mineral absorption 1.73 1.57e-2 48/60 (80%) MT1F;MT1E;MT1HL1;...
Nucleotide excision repair 1.70 2.49e-2 40/47 (85.11%) RPA3;RAD23B;POLE3;...
Mismatch repair 1.65 3.48e-2 22/23 (95.65%) RPA3;PCNA;RFC5;...
Non-alcoholic fatty liver disease 1.65 3.44e-2 126/155 (81.29%) CXCL8;CDC42;BAX;...
Proteasome 1.64 3.38e-2 44/46 (95.65%) PSME1;PSMA6;PSMB9;...
Alzheimer disease 1.61 3.92e-2 279/369 (75.61%) COX7B;NDUFB5;COX7A2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 2.22uM 24H