Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM7BSRH)

Drug Name
Tramiprosate Drug Info
Synonyms Alzhemed; Cerebril; Homotaurine; Vivimind; LU-02659; NC-531; NC-758; Tramiprosate (stroke), Neurochem; Tramiprosate (Alzheimer's disease), Neurochem; 3APS
Cross-matching ID
PubChem CID
1646
ChEBI ID
CHEMBL149082
CAS Number
CAS 3687-18-1
TTD Drug ID
D09DLP
VARIDT Drug ID
DR00760

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.29 0.00e+0 34/36 (94.44%) POLE2;RFC5;PCNA;...
Mineral absorption 2.02 8.47e-3 48/60 (80%) MT1M;MT1F;MT1X;...
IL-17 signaling pathway 1.88 8.47e-3 84/94 (89.36%) S100A9;LCN2;TNF;...
Steroid hormone biosynthesis 1.87 6.35e-3 43/61 (70.49%) UGT2B28;CYP3A5;DHRS11;...
Nitrogen metabolism 1.83 1.02e-2 16/17 (94.12%) GLUL;GLUD1;GLUD2;...
Metabolism of xenobiotics by cytochrome P450 1.82 8.47e-3 49/77 (63.64%) UGT2B28;CYP3A5;CBR3;...
Retinol metabolism 1.81 9.68e-3 41/68 (60.29%) ALDH1A2;ALDH1A1;UGT2B28;...
Parkinson disease 1.79 1.27e-2 176/249 (70.68%) DAXX;PPIF;NDUFV2;...
Mismatch repair 1.75 2.26e-2 22/23 (95.65%) RFC5;PCNA;RPA3;...
Peroxisome 1.72 2.96e-2 72/82 (87.8%) SCP2;FAR2;IDH2;...
Nucleotide excision repair 1.69 3.85e-2 40/47 (85.11%) POLE2;RFC5;PCNA;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 10uM 24H