Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM7DSYP)

Drug Name
Cefprozil Drug Info
Synonyms
Arzimol; Brisoral; Cefprozilo; Cefprozilum; Cefzil; Cronocef; Procef; Serozil; Cefprozil anhydrous; BMY 28100; Cefprozil (INN); Cefprozil (TN); Cefprozilo [INN-Spanish]; Cefprozilum [INN-Latin]; Cefzil (TN); Procef (TN); (6R,7R)-7-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-8-oxo-3-[(E)-prop-1-enyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (6R,7R)-7-{[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino}-8-oxo-3-(prop-1-en-1-yl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Therapeutic ClassAntibiotics
Cross-matching ID
PubChem CID
5281006
ChEBI ID
CHEMBL3506
CAS Number
CAS 92676-86-3
TTD Drug ID
D0YX4S
ACDINA Drug ID
D00110

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Oxidative phosphorylation 2.94 0.00e+0 93/133 (69.92%) COX7B;SDHD;NDUFB3;...
Ribosome 2.49 0.00e+0 113/158 (71.52%) MRPL13;MRPS11;RPL36;...
Parkinson disease 2.34 0.00e+0 176/249 (70.68%) COX7B;SDHD;NDUFB3;...
Huntington disease 2.33 0.00e+0 233/306 (76.14%) COX7B;SDHD;NDUFB3;...
Thermogenesis 2.26 0.00e+0 173/232 (74.57%) KRAS;COX7B;SDHD;...
Diabetic cardiomyopathy 2.23 0.00e+0 162/203 (79.8%) PLN;COX7B;SDHD;...
Prion disease 2.14 0.00e+0 209/273 (76.56%) COX7B;SDHD;NDUFB3;...
Non-alcoholic fatty liver disease 2.13 0.00e+0 126/155 (81.29%) COX7B;SDHD;NDUFB3;...
Amyotrophic lateral sclerosis 1.94 1.69e-3 267/364 (73.35%) COX7B;SDHD;NDUFB3;...
Alzheimer disease 1.92 2.28e-3 279/369 (75.61%) KRAS;COX7B;SDHD;...
Pathways of neurodegeneration 1.87 2.76e-3 354/475 (74.53%) KRAS;COX7B;SDHD;...
Propanoate metabolism 1.81 4.43e-3 30/34 (88.24%) DLD;LDHB;PCCB;...
RNA polymerase 1.79 8.18e-3 23/31 (74.19%) POLR2L;POLR2J;POLR2K;...
Retrograde endocannabinoid signaling 1.78 8.13e-3 118/148 (79.73%) NDUFB3;NDUFA7;NDUFA9;...
Pyruvate metabolism 1.69 2.13e-2 41/47 (87.23%) DLD;ALDH2;LDHB;...
Proteasome 1.65 2.70e-2 44/46 (95.65%) PSMA3;PSMA6;PSMD8;...
Aminoacyl-tRNA biosynthesis 1.64 2.99e-2 15/66 (22.73%) GATC;IARS2;WARS2;...
Riboflavin metabolism 1.63 2.91e-2 7/8 (87.5%) ACP1;RFK;ACP5;...
DNA replication 1.63 2.88e-2 34/36 (94.44%) POLE2;RFC2;RPA3;...
Citrate cycle (TCA cycle) 1.62 3.04e-2 30/30 (100%) SDHD;DLD;IDH2;...
Complement and coagulation cascades -1.95 6.10e-3 76/85 (89.41%) ITGAM;C4BPB;F13A1;...
ECM-receptor interaction -2.09 0.00e+0 80/88 (90.91%) DMP1;COL9A2;COL9A3;...
Protein digestion and absorption -2.12 0.00e+0 78/103 (75.73%) COL4A2;CPB2;COL21A1;...
Focal adhesion -2.16 0.00e+0 180/201 (89.55%) COL9A2;COL9A3;ITGB1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H