Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM7EN8I)

Drug Name
Diflunisal Drug Info
Synonyms
Adomal; Algobid; Citidol; Difludol; Diflunisalum; Dolisal; Dolobid; Dolobil; Dolobis; Dolocid; Flovacil; Fluniget; Fluodonil; Flustar; Noaldol; Reuflos; Unisal; Apotex Brand of Diflunisal; Cahill May Roberts Brand of Diflunisal; Diflunisal Novopharm Brand; Frosst SA Brand of Diflunisal; Merck Brand of Diflunisal; Novopharm Brand of Diflunisal; Nu Pharm Brand of Diflunisal; MK 647; MK647; Apo-Diflunisal; Diflunisalum [INN-Latin]; Dolobid (TN); MK-647; Merck Sharp & Dohme Brand of Diflunisal; Novo-Diflunisal; Nu-Diflunisal; Nu-Pharm Brand of Diflunisal; Diflunisal (JAN/USP/INN); Diflunisal [USAN:INN:BAN:JAN]; 2',4'-Difluoro-4-hydroxy-(1,1'-biphenyl)-3-carboxylic acid; 2',4'-Difluoro-4-hydroxy-3-biphenylcarboxylic acid; 2',4'-difluoro-4-hydroxybiphenyl-3-carboxylic acid; 2-(Hydroxy)-5-(2,4-difluorophenyl)benzoic acid; 5-(2,4-DIFLUOROPHENYL)-2-HYDROXY-BENZOIC ACID; 5-(2,4-Difluorophenyl)salicylic acid; 5-(2,4-difluorophenyl)-2-hydroxybenzoic acid; 5-[2,4-Difluorophenyl]salicylic acid
Therapeutic ClassAnalgesics
Cross-matching ID
PubChem CID
3059
ChEBI ID
CHEMBL898
CAS Number
CAS 22494-42-4
TTD Drug ID
D08LFZ
VARIDT Drug ID
DR00567
INTEDE Drug ID
DR0494
ACDINA Drug ID
D00197

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Natural killer cell mediated cytotoxicity 2.14 0.00e+0 99/131 (75.57%) PAK1;ITGB2;TNFSF10;...
DNA replication 2.10 4.47e-3 34/36 (94.44%) PCNA;MCM6;RFC2;...
PD-L1 expression and PD-1 checkpoint pathway in cancer 1.90 1.79e-2 79/89 (88.76%) STAT1;CD3D;RASGRP1;...
T cell receptor signaling pathway 1.82 2.23e-2 93/104 (89.42%) ITK;PAK1;CD3D;...
Th17 cell differentiation 1.81 1.97e-2 95/107 (88.79%) IL2RG;STAT1;CD3D;...
Mismatch repair 1.73 3.57e-2 22/23 (95.65%) PCNA;RFC2;RFC5;...
Th1 and Th2 cell differentiation 1.73 3.06e-2 80/92 (86.96%) IL2RG;STAT1;CD3D;...
IL-17 signaling pathway 1.72 3.46e-2 84/94 (89.36%) S100A8;LCN2;S100A7;...
Ovarian steroidogenesis -1.65 4.69e-2 41/51 (80.39%) HSD17B7;BMP6;LDLR;...
Fatty acid biosynthesis -1.66 4.43e-2 16/18 (88.89%) ACSBG1;ACSL3;ACSL1;...
Proteoglycans in cancer -1.68 3.63e-2 172/205 (83.9%) CASP3;HSPG2;HGF;...
Adipocytokine signaling pathway -1.70 3.16e-2 64/69 (92.75%) ACSBG1;ACSL3;IRS1;...
Glycerolipid metabolism -1.71 2.64e-2 44/61 (72.13%) LIPF;ALDH1B1;MBOAT2;...
Cysteine and methionine metabolism -1.72 2.67e-2 43/50 (86%) DNMT1;GSS;AHCYL2;...
Collecting duct acid secretion -1.72 2.84e-2 22/27 (81.48%) CLCNKB;ATP6V1B2;ATP6V0C;...
Fatty acid degradation -1.73 2.66e-2 40/43 (93.02%) ACAT1;CPT1A;ACAA1;...
Regulation of lipolysis in adipocytes -1.76 2.36e-2 52/55 (94.55%) PNPLA2;PTGER3;PIK3R2;...
Ferroptosis -1.76 2.55e-2 36/41 (87.8%) STEAP3;GCLC;PCBP2;...
Retinol metabolism -1.77 2.68e-2 41/68 (60.29%) RETSAT;UGT2B15;CYP2C8;...
Tryptophan metabolism -1.81 2.52e-2 35/42 (83.33%) ALDH2;KMO;KYAT3;...
alpha-Linolenic acid metabolism -1.81 2.80e-2 17/25 (68%) FADS2;PLA2G2A;PLAAT3
Protein digestion and absorption -1.82 2.60e-2 78/103 (75.73%) COL4A6;SLC7A9;PRSS3;...
Complement and coagulation cascades -1.84 2.66e-2 76/85 (89.41%) CPB2;SERPIND1;FGB;...
Arachidonic acid metabolism -1.89 1.64e-2 48/61 (78.69%) GPX3;GGT1;PTGIS;...
Terpenoid backbone biosynthesis -1.89 1.97e-2 18/22 (81.82%) PMVK;MVK;ACAT1;...
Glycine, serine and threonine metabolism -1.97 1.37e-2 31/40 (77.5%) AGXT;GLDC;PIPOX;...
ECM-receptor interaction -2.00 1.09e-2 80/88 (90.91%) THBS3;LAMB4;LAMA4;...
Steroid hormone biosynthesis -2.02 1.09e-2 43/61 (70.49%) HSD17B1;CYP11B2;STS;...
PPAR signaling pathway -2.16 0.00e+0 66/74 (89.19%) CPT1A;ACAA1;SORBS1;...
×

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 1.11uM - 10uM 24H
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Brain
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 1.11uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
MDA-MB-468 CVCL_0419 Homo sapiens 1.11uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
T-47D CVCL_0553 Homo sapiens 1.11uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 3H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
SNU-407 CVCL_5004 Homo sapiens 1.11uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 1.11uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 1.11uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 1.11uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 1.11uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
CJM CVCL_U797 Homo sapiens 1.11uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.04uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 12.5uM 72H
JHH-5 CVCL_1320 Homo sapiens 1.11uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
NCI-H1573 CVCL_1483 Homo sapiens 1.11uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 1.11uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 1.11uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 1.11uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
NCI-H2110 CVCL_1529 Homo sapiens 1.11uM - 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 1.11uM - 10uM 24H
Ovary
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVTOKO CVCL_3114 Homo sapiens 1.11uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 1.11uM - 10uM 24H
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H
IGR-37 CVCL_1303 Homo sapiens 1.11uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 1.11uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 1.11uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 1.11uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 1.11uM - 10uM 24H