Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM7F1PA)

• Drug Name: Nebivolol Drug Info
• Synonyms: Bystolic; Lobivon; Nebilet; Nebilong; Nebipill; Nebivololum; Nubeta; Nebivololum [Latin]; R 67555; Bystolic (TN); Nebicard-5;Nebilet (TN); Nebilong (TN); Nodon (TN); Nubeta (TN); PI-21858; R-67555; R65,824; Nebicard-5 (TN); Nebivolol (USAN/INN); Nebivolol [USAN:INN:BAN]; Alpha,alpha'-(Iminodimethylene)bis(6-fluoro-2-chromanmethanol); Alpha,alpha'-(Iminobis(methylene))bis(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol); Alpha,alpha'-(iminobis(methylene))bis(6-fluoro-3,4-dihydro)-2H-1-benzopyran-2-methanol; 1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-[[2-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-hydroxyethyl]amino]ethanol; 2,2'-iminobis[1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanol]
• Therapeutic Class: Antihypertensive Agents
• Cross-matching ID:
  PubChem CID: 71301
  ChEBI ID: CHEMBL434394
  CAS Number: CAS 99200-09-6
  TTD Drug ID: D0Z1UA
  INTEDE Drug ID: DR1134
  ACDINA Drug ID: D00459

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Ascorbate and aldarate metabolism	2.13	0.00e+0	15/30 (50%)	UGT2B4;UGT2B28;AKR1A1;...
Valine, leucine and isoleucine degradation	2.11	0.00e+0	42/48 (87.5%)	HMGCS1;ACAT2;HMGCS2;...
Pyruvate metabolism	2.08	0.00e+0	41/47 (87.23%)	PCK1;ADH5;ACAT2;...
Porphyrin and chlorophyll metabolism	1.99	8.02e-3	23/43 (53.49%)	UGT2B4;HEPH;UGT2B28;...
PPAR signaling pathway	1.98	8.56e-3	66/74 (89.19%)	FABP1;PCK1;FABP4;...
Glutathione metabolism	1.96	1.07e-2	43/57 (75.44%)	IDH2;GSTA1;GPX7;...
Butanoate metabolism	1.92	9.17e-3	23/28 (82.14%)	HMGCS1;ALDH5A1;ACAT2;...
Drug metabolism	1.92	8.02e-3	78/151 (51.66%)	ADH5;GSTA1;MAOB;...
Proximal tubule bicarbonate reclamation	1.91	8.32e-3	21/23 (91.3%)	PCK1;CA2;SLC4A4;...
Citrate cycle (TCA cycle)	1.91	8.56e-3	30/30 (100%)	PCK1;IDH2;MDH1;...
Oxidative phosphorylation	1.89	8.75e-3	93/133 (69.92%)	NDUFA3;NDUFA8;PPA1;...
Fatty acid degradation	1.88	9.80e-3	40/43 (93.02%)	ADH5;ECI2;ACAT2;...
Terpenoid backbone biosynthesis	1.87	1.23e-2	18/22 (81.82%)	HMGCS1;ACAT2;HMGCS2;...
Pentose and glucuronate interconversions	1.87	1.15e-2	17/34 (50%)	UGT2B4;AKR1B10;UGT2B28;...
Synthesis and degradation of ketone bodies	1.84	1.07e-2	9/10 (90%)	HMGCS1;ACAT2;HMGCS2;...
Tryptophan metabolism	1.84	1.27e-2	35/42 (83.33%)	MAOB;ACAT2;DHTKD1;...
Propanoate metabolism	1.81	1.51e-2	30/34 (88.24%)	ACAT2;ALDH6A1;ECHDC1;...
Glyoxylate and dicarboxylate metabolism	1.81	1.49e-2	23/30 (76.67%)	ACAT2;MDH1;PCCB;...
Protein export	1.80	1.52e-2	17/23 (73.91%)	SPCS1;SRPRB;SEC61B;...
Glycolysis / Gluconeogenesis	1.78	1.82e-2	56/67 (83.58%)	PCK1;ADH5;ALDOB;...
Steroid biosynthesis	1.78	1.78e-2	19/20 (95%)	MSMO1;CYP27B1;DHCR7;...
Tyrosine metabolism	1.76	1.90e-2	30/36 (83.33%)	ADH5;MAOB;ADH1B;...
Parkinson disease	1.73	2.46e-2	176/249 (70.68%)	GNAI1;CYCS;UCHL1;...
Mismatch repair	1.72	2.67e-2	22/23 (95.65%)	MSH2;RPA3;RFC1;...
Retinol metabolism	1.72	2.57e-2	41/68 (60.29%)	ADH5;ALDH1A1;UGT2B4;...
Metabolism of xenobiotics by cytochrome P450	1.71	2.67e-2	49/77 (63.64%)	ADH5;GSTA1;UGT2B4;...
DNA replication	1.69	3.01e-2	34/36 (94.44%)	MCM2;RPA3;RNASEH2A;...
Phenylalanine metabolism	1.67	3.59e-2	14/17 (82.35%)	MAOB;PAH;ALDH3A1;...
Vibrio cholerae infection	1.67	3.47e-2	44/50 (88%)	GNAS;PRKCA;ATP6V1H;...
Fatty acid elongation	1.66	3.78e-2	19/27 (70.37%)	TECR;HACD3;HSD17B12;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	24H	Hide ▲
MDA-MB-231	CVCL_0062	Homo sapiens	0.01uM - 10uM	24H	Hide ▲

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEK293	CVCL_0045	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Peripheral blood

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	0.01uM - 10uM	24H	Show ▼

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.04uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Umbilical vein

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HUVEC-C	CVCL_2959	Homo sapiens	0.01uM - 10uM	24H	Show ▼