Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM7H57T)

Drug Name
Metrizamide Drug Info
Synonyms metrizamide; Amipaque; Telebrix 300; 2-[[3-(Acetylamino)-5-(acetylmethylamino)-2,4,6-triiodobenzoyl]amino]-2-deoxy-D-glucose
Cross-matching ID
PubChem CID
443944
ChEBI ID
CHEMBL462394
CAS Number
CAS 31112-62-6
TTD Drug ID
D02VCJ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Proteasome 2.01 7.80e-3 44/46 (95.65%) PSMD2;PSMB10;PSMD14;...
Non-homologous end-joining 1.88 2.34e-2 11/13 (84.62%) DNTT;FEN1;MRE11;...
DNA replication 1.79 4.94e-2 34/36 (94.44%) DNA2;PCNA;FEN1;...
Sphingolipid metabolism -1.86 4.71e-2 32/49 (65.31%) GLA;PLPP1;GALC;...
Nitrogen metabolism -2.01 0.00e+0 16/17 (94.12%) CA14;CPS1;CA12;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 2.5uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H, 24H