Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM7I1T9)

Drug Name
Balsalazide Drug Info
Synonyms
Balsalazida; Balsalazida [Spanish]; Balsalazide Disodium; Balsalazide [INN:BAN]; Balsalazido; Balsalazido [Spanish]; Balsalazidum; Balsalazidum [Latin]; BX-661A; Colazide; BALSALAZIDE; P80AL8J7ZP; (E)-5-((4-(((2-Carboxyethyl)amino)carbonyl)phenyl)azo)-2-hydroxybenzoic acid; (E)-5-((4-((2-Carboxyethyl)carbamoyl)phenyl)diazenyl)-2-hydroxybenzoic acid; (E)-5-({p-[(2-carboxyethyl)carbamoyl]phenyl}azo)-2-salicylic acid; 80573-04-2; C17H15N3O6; CHEBI:267413; UNII-P80AL8J7ZP
Cross-matching ID
PubChem CID
54585
ChEBI ID
CHEMBL267413
CAS Number
CAS 80573-04-2
TTD Drug ID
D0A6KR
INTEDE Drug ID
DR2414

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
IL-17 signaling pathway 1.97 3.15e-2 84/94 (89.36%) CXCL1;S100A9;CXCL5;...
Rheumatoid arthritis 1.95 1.58e-2 78/93 (83.87%) CXCL1;CXCL5;CXCL8;...
Viral protein interaction with cytokine and cytokine re... 1.90 2.10e-2 84/100 (84%) CXCL1;CXCL5;CXCL8;...
Amoebiasis 1.87 2.37e-2 99/102 (97.06%) CXCL1;CXCL8;CXCL2;...
Neutrophil extracellular trap formation 1.87 1.89e-2 101/189 (53.44%) TLR4;FCGR3B;C5AR1;...
Systemic lupus erythematosus 1.82 2.28e-2 45/135 (33.33%) FCGR3B;HLA-DRB1;HLA-DRA;...
Asthma 1.81 2.40e-2 25/31 (80.65%) HLA-DRB1;HLA-DRA;HLA-DQA1;...
Th1 and Th2 cell differentiation 1.80 2.37e-2 80/92 (86.96%) JAG1;HLA-DRB1;MAF;...
NF-kappa B signaling pathway 1.77 2.80e-2 90/104 (86.54%) CXCL1;CXCL8;CXCL2;...
Staphylococcus aureus infection 1.72 4.84e-2 72/95 (75.79%) DEFA4;FCGR3B;C5AR1;...
TNF signaling pathway 1.71 4.97e-2 103/112 (91.96%) CXCL1;CXCL5;JAG1;...
Ovarian steroidogenesis -1.86 6.28e-3 41/51 (80.39%) HSD3B2;SCARB1;PLA2G4C;...
Hypertrophic cardiomyopathy -2.21 0.00e+0 81/90 (90%) CACNG1;CACNA1S;PRKAA1;...
Dilated cardiomyopathy -2.30 0.00e+0 86/96 (89.58%) MYH6;ADCY7;TPM2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 10uM 24H