Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM7I64Z)

• Drug Name: Almogran Drug Info
• Synonyms: Almotriptan; Axert; Almotriptan (USAN); Axert (TN); LAS-31416; PNU-180638; Almotriptan [USAN:INN:BAN]; N,N-dimethyl-2-[5-(pyrrolidin-1-ylsulfonylmethyl)-1H-indol-3-yl]ethanamine; N,N-dimethyl-2-{5-[(pyrrolidin-1-ylsulfonyl)methyl]-1H-indol-3-yl}ethanamine; 1-(((3-(2-(Dimethylamino)ethyl)indol-5-yl)methyl)sulfonyl)pyrrolidine
• Therapeutic Class: Antimigraine Agents
• Cross-matching ID:
  PubChem CID: 123606
  ChEBI ID: CHEMBL520985
  CAS Number: CAS 154323-57-6
  TTD Drug ID: D0P0SM
  ACDINA Drug ID: D00021

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Complement and coagulation cascades	2.39	0.00e+0	76/85 (89.41%)	CLU;SERPINA1;SERPINA5;...
Tryptophan metabolism	1.98	6.48e-3	35/42 (83.33%)	TDO2;ALDH3A2;CYP1A1;...
Dilated cardiomyopathy	1.90	1.73e-2	86/96 (89.58%)	ACTB;AGT;TNNC1;...
Platelet activation	1.87	1.94e-2	106/124 (85.48%)	ACTB;RAP1A;FGG;...
Fatty acid degradation	1.83	2.07e-2	40/43 (93.02%)	ACSL1;ACSL5;ALDH3A2;...
Hypertrophic cardiomyopathy	1.81	2.81e-2	81/90 (90%)	ACTB;AGT;TNNC1;...
Pyruvate metabolism	1.80	2.78e-2	41/47 (87.23%)	ALDH3A2;ADH1B;LDHA;...
Valine, leucine and isoleucine degradation	1.79	2.43e-2	42/48 (87.5%)	ALDH3A2;ALDH6A1;BCKDHA;...
Ribosome	1.79	2.45e-2	113/158 (71.52%)	RPL26L1;RPS27L;MRPL13;...
Histidine metabolism	1.75	3.24e-2	16/22 (72.73%)	ALDH3A2;HNMT;HAL;...
B cell receptor signaling pathway	1.73	3.42e-2	71/81 (87.65%)	IFITM1;CD19;LILRA4;...
Leukocyte transendothelial migration	1.73	3.13e-2	90/114 (78.95%)	ACTB;RAP1A;CLDN10;...
Propanoate metabolism	1.72	3.39e-2	30/34 (88.24%)	SUCLG2;ALDH6A1;BCKDHA;...
Tight junction	1.69	4.54e-2	130/169 (76.92%)	ACTB;RDX;AMOTL2;...
Proteasome	1.69	4.23e-2	44/46 (95.65%)	PSMA2;PSMC3;PSMD6;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	10uM	6H	Hide ▲