Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM7ISKJ)

• Drug Name: Nisoldipine Drug Info
• Synonyms: Baymycard; Nisocor; Nisoldipin; Nisoldipino; Nisoldipinum; Sular; Syscor; Zadipina; Bay k 5552; Nisoldipino [INN-Spanish]; Nisoldipinum [INN-Latin]; Sular (TN); Bay-k-5552; Nisoldipine (JAN/USAN/INN); Nisoldipine [USAN:BAN:INN:JAN]; Isobutyl 1,4-dihydro-5-methoxycarbonyl-2,6-dimethyl-4-(2-nitrophenyl)-3-pyridincarboxylat;Methyl 2-methylpropyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; (+-)-Isobutyl methyl 1,4-dihydro-2,6-dimethyl-4-(o-nitrophenyl)-3,5-pyridinedicarboxylate; 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, methyl 2-methylpropyl ester; 3-O-methyl 5-O-(2-methylpropyl) 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• Therapeutic Class: Antihypertensive Agents
• Cross-matching ID:
  PubChem CID: 4499
  ChEBI ID: CHEMBL1726
  CAS Number: CAS 63675-72-9
  TTD Drug ID: D0S5CU
  VARIDT Drug ID: DR00668
  INTEDE Drug ID: DR1165
  ACDINA Drug ID: D00472

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
IL-17 signaling pathway	1.95	2.32e-2	84/94 (89.36%)	CXCL1;S100A9;IL1B;...
PPAR signaling pathway	-1.70	4.12e-2	66/74 (89.19%)	ACAA1;SORBS1;APOC3;...
Biosynthesis of unsaturated fatty acids	-1.73	3.53e-2	21/27 (77.78%)	BAAT;SCP2;HACD1;...
Oxidative phosphorylation	-1.81	2.04e-2	93/133 (69.92%)	ATP6V1G1;NDUFA8;COX11;...
Metabolism of xenobiotics by cytochrome P450	-1.86	1.48e-2	49/77 (63.64%)	CYP1A2;CYP2C9;GSTM5;...
Steroid hormone biosynthesis	-2.00	0.00e+0	43/61 (70.49%)	HSD17B12;AKR1C3;CYP1A2;...
Cholesterol metabolism	-2.09	0.00e+0	44/50 (88%)	VDAC3;CYP27A1;SCARB1;...
Steroid biosynthesis	-2.12	0.00e+0	19/20 (95%)	SQLE;DHCR24;SC5D;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	0.12uM - 10uM	6H, 24H, 48H	Hide ▲

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.12uM - 10uM	6H, 24H, 48H	Hide ▲

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	10uM	6H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	10uM	6H	Show ▼

Liver

Hepatocellular carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HuH-7	CVCL_0336	Homo sapiens	8uM	72H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.12uM - 10uM	6H, 24H, 48H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	10uM	6H	Show ▼