Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM7KJTI)

Drug Name
PD-153035 Drug Info
Synonyms
183322-45-4; PD153035 hydrochloride; N-(3-Bromophenyl)-6,7-dimethoxyquinazolin-4-amine hydrochloride; PD153035 HCl; PD 153035 HYDROCHLORIDE; PD-153035 hydrochloride; PD153035 (Hydrochloride); Tyrphostin AG 1517; AG 1517 hydrochloride; SU-5271 hydrochloride; UNII-AHJ252P69N; ZM 252868; SU 5271; AG 1517; 4-[(3-BROMOPHENYL)AMINO]-6,7-DIMETHOXYQUINAZOLINE HYDROCHLORIDE; AHJ252P69N; pd 153035; PD153035.HCl; CHEMBL1204168; 6,7-Dimethoxy-4-[N-(3-bromophenyl)amino]quinazoline hydrochloride; C16H15BrClN3O2; 4-Quinazolinamine, N-(3-bromo
Cross-matching ID
PubChem CID
4705
ChEBI ID
CHEMBL29197
CAS Number
CAS 153436-54-5
TTD Drug ID
D0Q7HO

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Mucin type O-glycan biosynthesis 1.94 2.92e-2 20/36 (55.56%) GALNT7;ST6GALNAC2;GALNT6;...
Toxoplasmosis -1.64 4.66e-2 103/112 (91.96%) LAMC1;MYD88;MAPK1;...
Sulfur relay system -1.68 3.01e-2 5/8 (62.5%) MPST;NFS1;MOCS2
Glycolysis / Gluconeogenesis -1.68 3.13e-2 56/67 (83.58%) ALDH3A2;LDHA;ADH1B;...
Th1 and Th2 cell differentiation -1.68 3.10e-2 80/92 (86.96%) IL2RB;TYK2;PLCG1;...
Phagosome -1.69 2.85e-2 118/152 (77.63%) RAB5C;ATP6V1C1;TAP1;...
Legionellosis -1.70 2.98e-2 51/57 (89.47%) CXCL8;CXCL2;RAB1A;...
Citrate cycle (TCA cycle) -1.72 2.63e-2 30/30 (100%) MDH1;ACLY;OGDH;...
Hematopoietic cell lineage -1.73 2.57e-2 90/99 (90.91%) CD1D;CR2;IL11RA;...
Herpes simplex virus 1 infection -1.73 2.50e-2 165/498 (33.13%) TICAM1;EIF2S1;BAX;...
Influenza A -1.74 2.21e-2 156/172 (90.7%) TICAM1;EIF2S1;BAX;...
Pathogenic Escherichia coli infection -1.75 2.12e-2 152/197 (77.16%) CHUK;MYO10;MYH9;...
Viral protein interaction with cytokine and cytokine re... -1.76 1.77e-2 84/100 (84%) IL6R;IL24;IL22RA1;...
TNF signaling pathway -1.77 1.88e-2 103/112 (91.96%) JUNB;CHUK;IRF1;...
Retinol metabolism -1.80 1.28e-2 41/68 (60.29%) CYP3A7;CYP2C8;ADH1C;...
Inflammatory bowel disease -1.81 1.38e-2 58/65 (89.23%) IL4R;HLA-DPA1;STAT3;...
Systemic lupus erythematosus -1.85 9.63e-3 45/135 (33.33%) CD28;CD80;ACTN4;...
Ribosome -1.85 1.05e-2 113/158 (71.52%) MRPL22;RPLP1;RPS18;...
Asthma -1.86 1.03e-2 25/31 (80.65%) HLA-DPA1;HLA-DRA;TNF;...
Antigen processing and presentation -1.87 1.14e-2 60/78 (76.92%) CD74;NFYA;HLA-DPA1;...
Pyruvate metabolism -1.94 4.82e-3 41/47 (87.23%) ACYP2;MDH1;ACYP1;...
Pertussis -1.94 5.51e-3 64/76 (84.21%) TICAM1;RELA;NLRP3;...
Autoimmune thyroid disease -1.97 4.28e-3 46/53 (86.79%) TSHB;IL2;CGA;...
Viral myocarditis -1.98 2.57e-3 53/60 (88.33%) HLA-DPA1;HLA-E;HLA-DRA;...
Graft-versus-host disease -2.03 3.21e-3 32/42 (76.19%) HLA-DPA1;HLA-E;HLA-DRA;...
Type I diabetes mellitus -2.08 4.28e-3 38/43 (88.37%) HLA-DPA1;HLA-E;HLA-DRA;...
Proteasome -2.09 6.42e-3 44/46 (95.65%) PSME2;PSMC4;PSMB3;...
Allograft rejection -2.17 0.00e+0 32/38 (84.21%) HLA-DPA1;HLA-E;HLA-DRA;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 3H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.04uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H