Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM7MLTR)

Drug Name
Itopride Drug Info
Synonyms
Itopride; Itopride (INN); Itopride [INN]; QQQIECGTIMUVDS-UHFFFAOYSA-N; SCHEMBL311309; SR-01000763470; 122898-67-3; 81BMQ80QRL; AC1L1GQ2; AC1Q5DLT; DTXSID7048320; N-(4-(2-(Dimethylamino)ethoxy)benzyl)-3,4-dimethoxybenzamide; N-({4-[2-(dimethylamino)ethoxy]phenyl}methyl)-3,4-dimethoxybenzamide; N-[4-[2-(Dimethylamino)ethoxy]benzyl]-3,4-dimethoxybenzamide; N-[[4-[2-(dimethylamino)ethoxy]phenyl]methyl]-3,4-dimethoxybenzamide; NCGC00167529-01; UNII-81BMQ80QRL; n-{4-[2-(dimethylamino)ethoxy]benzyl}-3,4-dimethoxybenzamide
Cross-matching ID
PubChem CID
3792
ChEBI ID
CHEMBL94809
CAS Number
CAS 122898-67-3
INTEDE Drug ID
DR0893

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Metabolism of xenobiotics by cytochrome P450 2.09 0.00e+0 49/77 (63.64%) HSD11B1;UGT2B4;UGT2B28;...
Complement and coagulation cascades 2.05 0.00e+0 76/85 (89.41%) TFPI;A2M;C4BPA;...
Proximal tubule bicarbonate reclamation 1.95 2.70e-3 21/23 (91.3%) AQP1;PCK1;GLUD1;...
Primary bile acid biosynthesis 1.94 2.02e-3 15/17 (88.24%) AMACR;CH25H;AKR1C4;...
Mineral absorption 1.93 1.62e-3 48/60 (80%) MT1F;MT1M;MT1G;...
Propanoate metabolism 1.88 1.35e-3 30/34 (88.24%) ACOX1;ALDH6A1;PCCA;...
Drug metabolism 1.86 4.62e-3 78/151 (51.66%) UGT2B4;UGT2B28;ADH6;...
PPAR signaling pathway 1.85 5.06e-3 66/74 (89.19%) FABP1;PPARG;LPL;...
Peroxisome 1.82 7.19e-3 72/82 (87.8%) PECR;AMACR;ACSL5;...
Butanoate metabolism 1.81 8.09e-3 23/28 (82.14%) ALDH5A1;ACAT2;GAD1;...
Bile secretion 1.80 1.25e-2 68/90 (75.56%) AQP1;ABCC4;AQP4;...
Hematopoietic cell lineage 1.79 1.15e-2 90/99 (90.91%) CD9;CD59;CD8A;...
Pyruvate metabolism 1.75 1.62e-2 41/47 (87.23%) PCK1;ADH6;ADH1A;...
Fatty acid degradation 1.74 1.56e-2 40/43 (93.02%) ACSL5;ACOX1;ADH6;...
Oxidative phosphorylation 1.74 1.51e-2 93/133 (69.92%) ATP6V1D;COX7A2;NDUFA3;...
Arginine biosynthesis 1.73 1.62e-2 17/22 (77.27%) ARG1;GLUD1;GLUL;...
Tryptophan metabolism 1.72 1.67e-2 35/42 (83.33%) MAOA;MAOB;TDO2;...
Phenylalanine metabolism 1.68 2.34e-2 14/17 (82.35%) PAH;MAOA;MAOB;...
Synthesis and degradation of ketone bodies 1.63 3.92e-2 9/10 (90%) ACAT2;BDH2;HMGCL;...
Retinol metabolism 1.62 4.00e-2 41/68 (60.29%) UGT2B4;HSD17B6;UGT2B28;...
Tyrosine metabolism 1.60 4.35e-2 30/36 (83.33%) ADH6;MAOA;MAOB;...
Arginine and proline metabolism 1.60 4.38e-2 39/50 (78%) ARG1;MAOA;ODC1;...
Valine, leucine and isoleucine degradation 1.58 4.82e-2 42/48 (87.5%) ALDH6A1;PCCA;ACADM;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 10uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 3.33uM 24H