Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM7NKEV)

Drug Name
Thioguanine Drug Info
Synonyms
6-thioguanine; Lanvis; THG; Tabloid; ThioguaninGSK; Tioguanin; Tioguanina; Tioguanine; Tioguaninum; Glaxo Wellcome Brand of Thioguanine; Glaxo Wellcome Brand of Tioguanine; GlaxoSmithKline Brand of Thioguanine; GlaxoSmithKline Brand of Tioguanine; Thioguanin GSK; Thioguanine Hemihydrate; Thioguanine Monosodium Salt; Thioguanine Tabloid; Tioguanina Wellcome; Tioguanine GlaxoSmithKline Brand; Wellcome Brand of Thioguanine; BW 5071; DX4; LT00455187; Wellcome U3B; Lanvis (TN); Thioguanin-GSK; Thioguanine [USAN:BAN]; Tioguanina[INN-Spanish]; Tioguanine (INN); Tioguaninum [INN-Latin]; Purine antimetabolite: antimetabolite: inhibits nucleic acid replication; Guanine, thio-(VAN); 2 Amino 6 Purinethiol; 2-Amino 6MP; 2-Amino-1,7-dihydro-6H-purin-6-thion; 2-Amino-1,7-dihydro-6H-purin-6-thion [Czech]; 2-Amino-1,7-dihydro-6H-purine-6-thione; 2-Amino-6-MP; 2-Amino-6-mercaptopurine; 2-Amino-6-merkaptopurin; 2-Amino-6-merkaptopurin [Czech]; 2-Amino-6-purinethiol; 2-Amino-9H-purine-6-thiol; 2-Aminopurin-6-thiol; 2-Aminopurin-6-thiol [Czech]; 2-Aminopurine-6(1H)-thione; 2-Aminopurine-6-thiol; 2-Thioguanine; 2-amino-3,7-dihydropurine-6-thione; 6 Thioguanine; 6-Mercapto-2-aminopurine; 6-Mercaptoguanine; 6-TG; 6-Thioguanine; 6-Thioguanine (6-TG); 6-Thioguanine, Thioguanine; Thioguanine (Guanine analog)
Therapeutic ClassAnticancer Agents
Cross-matching ID
PubChem CID
2723601
ChEBI ID
CHEMBL9555
CAS Number
CAS 154-42-7
TTD Drug ID
D02ZXM
VARIDT Drug ID
DR00510
INTEDE Drug ID
DR1597
ACDINA Drug ID
D00671

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
TNF signaling pathway 1.96 1.01e-2 103/112 (91.96%) ATF4;CXCL1;CXCL5;...
Mitophagy 1.90 1.52e-2 56/68 (82.35%) ATF4;CITED2;SQSTM1;...
p53 signaling pathway 1.80 4.30e-2 63/73 (86.3%) DDB2;BAX;CDK1;...
Glycine, serine and threonine metabolism 1.79 3.44e-2 31/40 (77.5%) PSAT1;PHGDH;SHMT2;...
Calcium signaling pathway -1.63 3.14e-2 213/240 (88.75%) ERBB2;CAMK1;ATP2A3;...
Prion disease -1.64 2.87e-2 209/273 (76.56%) ITPR3;PSMB3;CAV3;...
Glyoxylate and dicarboxylate metabolism -1.64 2.79e-2 23/30 (76.67%) MDH2;MDH1;MMUT;...
Arginine and proline metabolism -1.64 2.90e-2 39/50 (78%) ALDH18A1;GOT2;SMS;...
Arrhythmogenic right ventricular cardiomyopathy -1.65 2.82e-2 70/77 (90.91%) DSC2;ITGA9;ACTB;...
Adrenergic signaling in cardiomyocytes -1.68 2.22e-2 130/150 (86.67%) BCL2;ATP2B2;CALML5;...
Thermogenesis -1.69 1.94e-2 173/232 (74.57%) COX6A2;ATP5ME;PPARG;...
Peroxisome -1.75 1.03e-2 72/82 (87.8%) BAAT;PEX11A;PECR;...
Fructose and mannose metabolism -1.75 1.04e-2 30/33 (90.91%) HKDC1;FPGT;ALDOA;...
Butanoate metabolism -1.76 9.91e-3 23/28 (82.14%) BDH1;ALDH5A1;EHHADH;...
Biosynthesis of unsaturated fatty acids -1.80 5.94e-3 21/27 (77.78%) ELOVL4;ACOX3;SCD5;...
Pyruvate metabolism -1.81 6.26e-3 41/47 (87.23%) ADH1B;PKLR;MDH2;...
Terpenoid backbone biosynthesis -1.85 3.85e-3 18/22 (81.82%) DHDDS;MVD;PDSS1;...
Vitamin digestion and absorption -1.86 3.50e-3 17/24 (70.83%) TCN2;SLC19A3;SLC19A2;...
Citrate cycle (TCA cycle) -1.87 3.71e-3 30/30 (100%) MDH2;MDH1;CS;...
Starch and sucrose metabolism -1.88 3.96e-3 25/36 (69.44%) HKDC1;GYG2;GBE1;...
Synthesis and degradation of ketone bodies -1.90 3.54e-3 9/10 (90%) ACAT1;HMGCS2;ACAT2;...
Cholesterol metabolism -1.90 3.81e-3 44/50 (88%) ABCG5;ABCB11;LRPAP1;...
Hypertrophic cardiomyopathy -1.92 1.65e-3 81/90 (90%) ITGA2B;ITGA2;ITGB7;...
Oxidative phosphorylation -1.94 9.01e-4 93/133 (69.92%) COX6A2;ATP5ME;ATP5PF;...
Dilated cardiomyopathy -1.98 9.91e-4 86/96 (89.58%) ITGA2B;ITGA2;ITGB7;...
Fatty acid degradation -1.98 1.10e-3 40/43 (93.02%) ECI1;ALDH7A1;ADH1B;...
Diabetic cardiomyopathy -2.00 1.24e-3 162/203 (79.8%) ATP5PF;NDUFV1;VDAC1;...
PPAR signaling pathway -2.00 1.42e-3 66/74 (89.19%) ANGPTL4;ACOX3;FABP6;...
Fat digestion and absorption -2.01 1.65e-3 35/43 (81.4%) GOT2;DGAT1;APOA4;...
Cardiac muscle contraction -2.02 0.00e+0 64/87 (73.56%) COX6A2;TRDN;MYH7;...
Steroid biosynthesis -2.06 0.00e+0 19/20 (95%) LIPA;SC5D;EBP;...
Valine, leucine and isoleucine degradation -2.07 0.00e+0 42/48 (87.5%) AACS;ALDH7A1;BCAT2;...
Propanoate metabolism -2.08 0.00e+0 30/34 (88.24%) MMUT;ACOX3;DLD;...
Complement and coagulation cascades -2.12 0.00e+0 76/85 (89.41%) C8A;CD55;F9;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H