Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM7Q41G)

Drug Name
Pyruvic acid Drug Info
Synonyms
BTS; Brenztraubensaeure; Acetylformic acid; Acide pyruvique; Pyroracemic acid; CH3COCOOH; A-Ketopropionic acid; Alpha-Ketopropionic acid; Alpha-Oxopropionsaeure; Alpha-keto propionic acid; Alpha-ketopropionic acid; P-9250; Pyruvic acid (8CI); Pyruvic acid (natural); Propanoic acid, 2-oxo-(9CI); 2-Ketopropionic acid; 2-Oxopropanoate; 2-Oxopropanoic acid; 2-Oxopropansaeure; 2-Oxopropionic acid; 2-Oxopropionsaeure; 2-oxo(1-14c)propanoic acid; 2-oxo-propionic acid
Therapeutic ClassDietary supplement
Cross-matching ID
PubChem CID
1060
ChEBI ID
CHEMBL1162144
CAS Number
CAS 127-17-3
TTD Drug ID
D0G4JI
VARIDT Drug ID
DR01397

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Protein export -1.76 2.81e-2 17/23 (73.91%) SRP14;SPCS1;SEC61B;...
Parkinson disease -1.77 2.52e-2 176/249 (70.68%) ATP5PF;PSMA5;MAP3K5;...
Thermogenesis -1.79 2.29e-2 173/232 (74.57%) ACSL5;RPS6KA2;ACTL6A;...
Huntington disease -1.80 2.62e-2 233/306 (76.14%) ATP5PF;PSMA5;MAP3K5;...
Staphylococcus aureus infection -1.88 8.99e-3 72/95 (75.79%) MBL2;PTAFR;HLA-DRA;...
Ribosome -1.90 4.32e-3 113/158 (71.52%) RPL11;RPS15A;RPL13;...
Systemic lupus erythematosus -1.91 5.40e-3 45/135 (33.33%) HLA-DRA;HLA-DQB1;C7;...
Oxidative phosphorylation -1.97 0.00e+0 93/133 (69.92%) NDUFA10;ATP6V0E1;ATP5MG;...
Citrate cycle (TCA cycle) -2.00 0.00e+0 30/30 (100%) SUCLG1;MDH1;IDH1;...
Complement and coagulation cascades -2.50 0.00e+0 76/85 (89.41%) F11;C8A;F12;...
×

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 20uM 6H