Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM7RXQ6)

Drug Name
androstenol Drug Info
Synonyms
5alpha-Androst-16-en-3alpha-ol; Androstenol; 1153-51-1; Androst-16-en-3alpha-ol; 16,17-ANDROSTENE-3-OL; Androst-16-en-3-ol; 3alpha-Hydroxyandrost-16-ene; alpha-androstenol; UNII-48K9VAM062; (3alpha,5alpha)-Androst-16-en-3-ol; Androst-16-en-3-ol, (3alpha,5alpha)-; CHEMBL142348; CHEBI:40933; KRVXMNNRSSQZJP-PHFHYRSDSA-N; 48K9VAM062; Androst-16-en-3-ol, (3a,5a)-; androst-16-en-3-ol; 16,17-Androstene-3-Ol
Cross-matching ID
PubChem CID
101989
ChEBI ID
CHEMBL40933
CAS Number
CAS 1153-51-1
TTD Drug ID
D08XML

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.13 0.00e+0 34/36 (94.44%) POLE2;FEN1;LIG1;...
Mismatch repair 1.89 8.93e-3 22/23 (95.65%) LIG1;RFC5;RFC2;...
Cell cycle 1.84 2.08e-2 110/124 (88.71%) CDC45;SMC1A;CCND2;...
Fanconi anemia pathway 1.83 2.01e-2 36/54 (66.67%) FANCA;RAD51;HES1;...
Pyrimidine metabolism 1.80 2.50e-2 40/56 (71.43%) CANT1;RRM2;RRM1;...
Base excision repair 1.76 3.12e-2 29/33 (87.88%) POLE2;FEN1;LIG1;...
Vitamin digestion and absorption -1.75 4.92e-2 17/24 (70.83%) SLC19A3;ABCC1;LMBRD1;...
Complement and coagulation cascades -1.89 1.67e-2 76/85 (89.41%) MBL2;F2;THBD;...
PPAR signaling pathway -1.91 1.78e-2 66/74 (89.19%) GK;NR1H3;PCK1;...
Protein processing in endoplasmic reticulum -1.95 1.94e-2 127/171 (74.27%) CRYAA;RPN1;BCL2;...
Ferroptosis -1.97 1.85e-2 36/41 (87.8%) NCOA4;CYBB;FTL;...
Arginine biosynthesis -2.02 1.11e-2 17/22 (77.27%) OTC;GLUL;ARG1;...
Ribosome -2.02 1.11e-2 113/158 (71.52%) RPS13;RPL6;RPL9;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Fibroblast
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
FIBRNPC CVCL_UK07 Homo sapiens 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
1HAEo- CVCL_0128 Homo sapiens 10uM 24H
NL20 CVCL_0461 Homo sapiens 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Normal (Fibroblast)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HFL1 CVCL_4295 Homo sapiens 10uM 24H
IMR-90 CVCL_0347 Homo sapiens 10uM 24H
WI-38 CVCL_0579 Homo sapiens 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H