Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM7TOWX)

Drug Name
ABT-333 Drug Info
Synonyms
Dasabuvir; 1132935-63-7; ABT-333; N-(6-(3-(tert-butyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxyphenyl)naphthalen-2-yl)methanesulfonamide; ABT333; UNII-DE54EQW8T1; ABT 333; Dasabuvir (ABT-333); DE54EQW8T1; CHEBI:85182; N-(6-(3-tert-Butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxyphenyl)naphthalen-2-yl)methanesulfonamide; C26H27N3O5S; Dasabuvir [INN]; N-{6-[3-tert-butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxyphenyl]naphthalen-2-yl}methanesulfonamide; Dasabuvir [USAN:INN]; Dasabuvir (USA
Cross-matching ID
PubChem CID
56640146
ChEBI ID
CHEMBL3137312
CAS Number
CAS 1132935-63-7
TTD Drug ID
D04KJT
VARIDT Drug ID
DR01289
INTEDE Drug ID
DR0422

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Proteasome 2.05 7.14e-3 44/46 (95.65%) PSMB9;PSMB8;PSME1;...
Hematopoietic cell lineage 1.83 2.14e-2 90/99 (90.91%) CD9;CD55;MME;...
DNA replication 1.77 3.09e-2 34/36 (94.44%) RPA3;RFC4;RNASEH2A;...
IL-17 signaling pathway 1.73 3.93e-2 84/94 (89.36%) MMP9;S100A8;S100A9;...
Drug metabolism 1.73 3.28e-2 78/151 (51.66%) MPO;GSTT2;AOX1;...
Platelet activation -1.64 4.47e-2 106/124 (85.48%) ADCY8;FGA;GUCY1B1;...
Adipocytokine signaling pathway -1.65 4.62e-2 64/69 (92.75%) CPT1A;IKBKG;ACSBG1;...
Long-term depression -1.66 4.52e-2 55/60 (91.67%) GUCY1B1;GNA13;ITPR1;...
Insulin resistance -1.66 4.62e-2 96/108 (88.89%) MAPK8;AKT1;TBC1D4;...
Endocrine and other factor-regulated calcium reabsorpti... -1.70 3.81e-2 49/53 (92.45%) SLC8A1;RAB11A;ADCY6;...
AMPK signaling pathway -1.70 4.04e-2 106/120 (88.33%) INS;STRADA;SREBF1;...
Growth hormone synthesis, secretion and action -1.72 3.17e-2 108/119 (90.76%) PRKCB;ADCY8;MAP3K1;...
Glucagon signaling pathway -1.74 2.26e-2 89/107 (83.18%) PRKAB2;PPP3CA;PRKAA1;...
Cortisol synthesis and secretion -1.74 2.34e-2 58/65 (89.23%) ADCY8;NR4A1;ATF4;...
Morphine addiction -1.74 2.53e-2 80/91 (87.91%) GRK6;GNG7;PDE4A;...
Cocaine addiction -1.77 1.68e-2 42/49 (85.71%) BDNF;DRD1;DRD2;...
Chagas disease -1.79 1.58e-2 93/102 (91.18%) IRAK4;ADCY1;PLCB3;...
Thyroid hormone signaling pathway -1.79 1.76e-2 112/121 (92.56%) MDM2;AKT1;TBC1D4;...
Inositol phosphate metabolism -1.83 1.16e-2 66/73 (90.41%) IMPA1;PLCB3;PIP5K1A;...
Circadian entrainment -1.88 5.66e-3 85/97 (87.63%) PER2;GNB1;GNG12;...
Dopaminergic synapse -1.90 4.40e-3 115/132 (87.12%) GNB1;GNG12;PPP3CA;...
Phosphatidylinositol signaling system -1.91 5.28e-3 82/97 (84.54%) PIP5K1B;MTMR3;ITPKB;...
Insulin secretion -1.91 6.60e-3 75/86 (87.21%) KCNMB3;ATP1A3;PRKCB;...
Vascular smooth muscle contraction -1.95 0.00e+0 113/133 (84.96%) PPP1CC;MAP2K1;PRKG1;...
Vasopressin-regulated water reabsorption -1.95 0.00e+0 40/44 (90.91%) DYNC1H1;AQP4;CREB3L1;...
Renin secretion -2.06 0.00e+0 61/69 (88.41%) PTGER4;GUCY1B1;AGTR1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 2.22uM 24H