Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM7USVA)

Drug Name
Duvelisib Drug Info
Synonyms
Duvelisib; 1201438-56-3; IPI-145; INK-1197; UNII-610V23S0JI; IPI 145; 610V23S0JI; INK-1147; Copiktra; IPI-145 (INK1197); Duvelisib [USAN:INN]; IPI145; INK1197; Copiktra (TN); AK145604; Duvelisib (IPI-145, INK1197); Duvel; Duvelisib
Therapeutic ClassAntiviral Agents
Cross-matching ID
PubChem CID
50905713
ChEBI ID
CHEMBL3039502
CAS Number
CAS 1201438-56-3
TTD Drug ID
D06ZVZ
ACDINA Drug ID
D01025

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Bladder cancer -1.67 2.60e-2 40/41 (97.56%) MAP2K2;E2F1;DAPK3;...
Viral carcinogenesis -1.68 2.56e-2 149/203 (73.4%) IRF7;GRB2;GTF2E1;...
Amino sugar and nucleotide sugar metabolism -1.68 2.57e-2 38/48 (79.17%) GFPT2;HKDC1;HK3;...
Steroid biosynthesis -1.68 2.57e-2 19/20 (95%) CYP24A1;HSD17B7;TM7SF2;...
Toll-like receptor signaling pathway -1.69 2.49e-2 94/104 (90.38%) CHUK;CD86;CXCL10;...
Fluid shear stress and atherosclerosis -1.74 1.29e-2 123/139 (88.49%) PRKCZ;CTNNB1;CAV2;...
Biosynthesis of unsaturated fatty acids -1.75 1.05e-2 21/27 (77.78%) ELOVL6;SCD;FADS1;...
Salmonella infection -1.76 1.09e-2 198/249 (79.52%) IL18;CTNNB1;HRAS;...
Glycine, serine and threonine metabolism -1.76 1.09e-2 31/40 (77.5%) CBS;PIPOX;AGXT;...
Lipid and atherosclerosis -1.78 7.42e-3 190/215 (88.37%) ROCK2;CHUK;POU2F2;...
Synaptic vesicle cycle -1.78 7.79e-3 63/78 (80.77%) SLC6A7;SLC1A7;ATP6V0A1;...
T cell receptor signaling pathway -1.79 8.20e-3 93/104 (89.42%) CHUK;IFNG;CD8A;...
Yersinia infection -1.80 7.32e-3 120/137 (87.59%) MAP2K3;ACTR2;PIK3CA;...
Proteasome -1.80 7.75e-3 44/46 (95.65%) PSMD12;PSMB10;PSMD11;...
Ferroptosis -1.83 6.74e-3 36/41 (87.8%) ATG7;GCLC;ACSL4;...
Osteoclast differentiation -1.84 5.59e-3 117/127 (92.13%) LILRA2;LCK;MAPK13;...
Apoptosis -1.88 4.28e-3 126/168 (75%) MAPK9;BBC3;DDIT3;...
B cell receptor signaling pathway -1.89 4.61e-3 71/81 (87.65%) INPP5D;PIK3CA;RASGRP3;...
Chemokine signaling pathway -1.93 4.99e-3 163/192 (84.9%) CXCL2;CCL27;CXCR2;...
Epithelial cell signaling in Helicobacter pylori infect... -1.93 5.45e-3 62/70 (88.57%) MAPK13;RELA;HBEGF;...
Cytokine-cytokine receptor interaction -1.95 3.60e-3 246/295 (83.39%) IL10;ACVR2A;CXCL2;...
PD-L1 expression and PD-1 checkpoint pathway in cancer -1.96 3.99e-3 79/89 (88.76%) CHUK;IFNG;HIF1A;...
Pathogenic Escherichia coli infection -1.99 3.00e-3 152/197 (77.16%) ROCK2;CTTN;CHUK;...
Leishmaniasis -1.99 3.42e-3 67/77 (87.01%) MAPK13;EEF1A2;HLA-DMB;...
Viral protein interaction with cytokine and cytokine re... -2.06 3.99e-3 84/100 (84%) CXCR1;IL10;CXCL2;...
Legionellosis -2.07 4.79e-3 51/57 (89.47%) EEF1A2;RELA;SAR1A;...
Rheumatoid arthritis -2.20 0.00e+0 78/93 (83.87%) CSF1;CSF2;ATP6V1A;...
TNF signaling pathway -2.21 0.00e+0 103/112 (91.96%) CEBPB;CREB3L1;MMP14;...
IL-17 signaling pathway -2.30 0.00e+0 84/94 (89.36%) CSF2;IL17RC;TRAF5;...
NF-kappa B signaling pathway -2.42 0.00e+0 90/104 (86.54%) TNFRSF11A;CARD10;CCL13;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone marrow
Chronic myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
K-562 CVCL_0004 Homo sapiens 0.01uM - 10uM 4H, 24H
Multiple myeloma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
KMS-34 CVCL_1333 Homo sapiens 0.01uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.5uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.5uM 6H
Lymph node
Burkitt lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BJAB CVCL_5711 Homo sapiens 0.01uM - 10uM 4H
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HBL-1 CVCL_4213 Homo sapiens 0.01uM - 10uM 4H, 24H
OCI-Ly10 CVCL_8795 Homo sapiens 0.01uM - 10uM 24H
OCI-Ly19 CVCL_8797 Homo sapiens 0.01uM - 10uM 4H, 24H
OCI-Ly3 CVCL_8796 Homo sapiens 0.01uM - 10uM 4H, 24H
TMD8 CVCL_A440 Homo sapiens 0.01uM - 10uM 4H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.5uM 6H
Peripheral blood
Acute B-lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NALM-6 CVCL_0092 Homo sapiens 0.01uM - 10uM 24H
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 4H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.5uM 6H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.5uM 6H
SK-MEL-5 CVCL_0527 Homo sapiens 0.01uM - 10uM 24H