Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM7W2ME)

• Drug Name: A61603 Drug Info
• Synonyms: A-61603; A 61603
• Cross-matching ID:
  PubChem CID: 4038180
  ChEBI ID: CHEMBL103854
  TTD Drug ID: D07OAF

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Lysosome	1.88	3.56e-2	115/128 (89.84%)	ACP2;HGSNAT;LAPTM4B;...
Intestinal immune network for IgA production	-1.71	4.75e-2	38/48 (79.17%)	CD80;AICDA;HLA-DQB1;...
Asthma	-1.73	4.91e-2	25/31 (80.65%)	CCL11;HLA-DQB1;FCER1G;...
Hypertrophic cardiomyopathy	-1.82	3.10e-2	81/90 (90%)	DES;TPM3;ITGA7;...
Graft-versus-host disease	-1.82	3.04e-2	32/42 (76.19%)	HLA-B;HLA-C;HLA-F;...
Arrhythmogenic right ventricular cardiomyopathy	-1.83	2.58e-2	70/77 (90.91%)	TCF7L2;DES;ITGA7;...
Cardiac muscle contraction	-1.85	2.76e-2	64/87 (73.56%)	TPM3;COX7A2L;ATP1A3;...
Viral myocarditis	-1.98	0.00e+0	53/60 (88.33%)	CASP8;HLA-B;HLA-C;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	10uM	6H	Hide ▲