Details of the Drug Pharmacogenomic Perturbation Atlas | DrugMAP

General Information of Drug (ID: DM7XC0U)

Drug Name	SIB-1553A Drug Info
Synonyms	191611-89-9; SIB 1553A hydrochloride; SIB 1553A Hyrdrochloride; SIB 1553A HCl; SCHEMBL6333252; SIB 1553A; MolPort-035-765-827; AKOS024458336; LS-104963; J-012387; (+/-)-4-[[2-(1-methyl-2-pyrrolidinyl)ethyl]thio]phenol hydrochloride; (+-)-4-((2-(1-Methyl-2-pyrrolidinyl)ethyl)thio)phenol hydrochloride; Phenol, 4-((2-(1-methyl-2-pyrrolidinyl)ethyl)thio)-, hydrochloride
Cross-matching ID	PubChem CID 5310968 ChEBI ID CHEMBL125446 CAS Number CAS 191611-76-4 TTD Drug ID D00ECO

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
African trypanosomiasis	2.07	0.00e+0	32/37 (86.49%)	HBB;VCAM1;IDO1;...
Salivary secretion	1.99	5.18e-3	76/93 (81.72%)	GNAS;PRKCA;SLC12A2;...
Tryptophan metabolism	1.96	6.91e-3	35/42 (83.33%)	DLD;IDO1;AOC1;...
Citrate cycle (TCA cycle)	1.92	5.18e-3	30/30 (100%)	DLD;ACLY;IDH2;...
Cardiac muscle contraction	1.90	4.14e-3	64/87 (73.56%)	TNNC1;TPM2;TPM4;...
Nitrogen metabolism	1.86	8.63e-3	16/17 (94.12%)	CA2;CA12;CA3;...
Glyoxylate and dicarboxylate metabolism	1.83	1.78e-2	23/30 (76.67%)	DLD;CS;MDH2;...
Proximal tubule bicarbonate reclamation	1.82	1.55e-2	21/23 (91.3%)	CA2;AQP1;SLC4A4;...
Gastric acid secretion	1.80	1.84e-2	63/76 (82.89%)	CA2;GNAS;PRKCA;...
Pancreatic secretion	1.76	2.38e-2	87/102 (85.29%)	CA2;GNAS;PRKCA;...
Staphylococcus aureus infection	1.69	4.14e-2	72/95 (75.79%)	KRT19;C1QA;KRT18;...
Leukocyte transendothelial migration	1.69	3.97e-2	90/114 (78.95%)	VCAM1;PRKCA;PIK3R1;...
Sphingolipid metabolism	-1.83	2.39e-2	32/49 (65.31%)	KDSR;CERS4;SGPL1;...
Protein processing in endoplasmic reticulum	-1.95	1.91e-2	127/171 (74.27%)	SEC61A2;EIF2AK3;HSP90AA1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Fibroblast

Nasopharyngeal carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
FIBRNPC	CVCL_UK07	Homo sapiens	10uM	6H, 24H