Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM7YWVT)

• Drug Name: PRX-321 Drug Info
• Synonyms: Silybin B; Milk thistle; 142797-34-0; UNII-853OHH1429; Flavobion; Legalon 70; 853OHH1429; CCRIS 7096; Wild Artichoke; Silybum marianum; Silybin A and B; Milk thistle [NF]; Silymarin + Melatonin; AC1LU7MH; UNII-U946SH95EE; Milk Thistle (Silybum marianum) Extract or Powder; SCHEMBL751461; Silybin B, analytical standard; U946SH95EE; CHEMBL592675; Milk Thistle (Silybum marianum) Extract or Powder [seed]; DTXSID30858697; SEBFKMXJBCUCAI-WAABAYLZSA-N; MolPort-039-139-345; ZINC1530850; BDBM50088491; 2717AH; AKOS015912848
• Therapeutic Class: Anticancer Agents
• Cross-matching ID:
  PubChem CID: 1548994
  ChEBI ID: CHEMBL592675
  CAS Number: CAS 65666-07-1
  TTD Drug ID: D0C5VQ
  VARIDT Drug ID: DR00878

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Complement and coagulation cascades	-1.71	3.68e-2	76/85 (89.41%)	SERPIND1;F13B;VWF;...
Pertussis	-1.74	2.69e-2	64/76 (84.21%)	MAPK13;CASP3;C3;...
TNF signaling pathway	-1.76	2.94e-2	103/112 (91.96%)	IL15;CCL2;TAB2;...
Retinol metabolism	-1.79	2.39e-2	41/68 (60.29%)	UGT2B4;CYP3A4;CYP2C18;...
Viral protein interaction with cytokine and cytokine re...	-1.80	2.87e-2	84/100 (84%)	CCL8;IL2RA;CCL2;...
Rheumatoid arthritis	-1.81	3.58e-2	78/93 (83.87%)	IL15;HLA-DMB;CCL2;...
Legionellosis	-1.89	2.09e-2	51/57 (89.47%)	HSPA8;RAB1B;RELA;...
IL-17 signaling pathway	-2.26	0.00e+0	84/94 (89.36%)	MMP13;PTGS2;MMP9;...
Mineral absorption	-2.34	0.00e+0	48/60 (80%)	SLC5A1;HEPH;SLC26A3;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.04uM - 10uM	24H	Hide ▲

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.04uM - 10uM	24H	Hide ▲

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	0.04uM - 10uM	24H	Show ▼

Peripheral blood

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.04uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.04uM - 10uM	24H	Show ▼