Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM802V7)

Drug Name
Syringic Acid Drug Info
Synonyms
SYRINGIC ACID; 530-57-4; 4-Hydroxy-3,5-dimethoxybenzoic acid; 3,5-Dimethoxy-4-hydroxybenzoic acid; Cedar acid; Gallic acid 3,5-dimethyl ether; Benzoic acid, 4-hydroxy-3,5-dimethoxy-; 3,5-Dimethoxy-4-hydroxybenzyl acid; UNII-E390O181H5; NSC 2129; EINECS 208-486-8; 4-Hydroxy-3,5-dimethoxy-benzoic acid; BRN 2115262; CHEMBL1414; AI3-24376; CHEBI:68329; JMSVCTWVEWCHDZ-UHFFFAOYSA-N; MFCD00002552; E390O181H5; Syringic acid, 97%; Syringlicacid; Syringicacid; PubChem2673; SpecPlus_000485; AC1L1VUN; Spectrum3_001866; Spectrum5_000963
Cross-matching ID
PubChem CID
10742
ChEBI ID
CHEMBL1414
CAS Number
CAS 530-57-4
TTD Drug ID
D0Q7DJ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Tyrosine metabolism 2.00 2.94e-2 30/36 (83.33%) HPD;MAOB;HGD;...
DNA replication 1.98 1.47e-2 34/36 (94.44%) FEN1;LIG1;MCM2;...
Phenylalanine metabolism 1.92 9.81e-3 14/17 (82.35%) PAH;HPD;MAOB;...
Complement and coagulation cascades 1.88 1.23e-2 76/85 (89.41%) FGG;SERPINA1;F5;...
Thyroid hormone synthesis 1.88 9.81e-3 66/75 (88%) ALB;PRKCA;GPX2;...
Lysine degradation 1.88 8.17e-3 51/63 (80.95%) ACAT2;ALDH9A1;KMT2A;...
Base excision repair 1.83 1.96e-2 29/33 (87.88%) FEN1;LIG1;POLE2;...
Mismatch repair 1.77 3.06e-2 22/23 (95.65%) MSH6;LIG1;RFC3;...
Tryptophan metabolism 1.71 4.90e-2 35/42 (83.33%) ACAT2;MAOB;ALDH9A1;...
Ribosome -1.87 4.58e-2 113/158 (71.52%) MRPS18A;RPS9;RPS12;...
Oxidative phosphorylation -1.96 3.05e-2 93/133 (69.92%) NDUFV1;NDUFA3;NDUFA8;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 2.5uM - 10uM 6H, 24H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 2.5uM - 10uM 6H, 24H