Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM804UR)

• Drug Name: Hyoscyamine Drug Info
• Synonyms: L-Hyoscyamine; hyoscyamine; 101-31-5; (-)-Hyoscyamine; Daturine; Duboisine; (-)-Atropine; L-Tropine tropate; (S)-Atropine; (S)-(-)-Hyoscyamine; Hyoscyamine (L); UNII-PX44XO846X; Tropine, (-)-tropate; Levbid; PX44XO846X; Levsinex SR; CHEBI:17486; Hyoscyamine, l-; [3(S)-endo]-alpha-(hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo[321]oct-3-yl ester; (2S)-(1R,5S)-8-Methyl-8-azabicyclo[321]octan-3-yl 3-hydroxy-2-phenylpropanoate; (1R,5S)-8-METHYL-8-AZABICYCLO[321]OCT-3-YL (2R)-3-HYDROXY-2-PHENYLPROPANOATE; Hyocyamine
• Therapeutic Class: Antiarrhythmic Agents
• Cross-matching ID:
  PubChem CID: 154417
  ChEBI ID: CHEMBL2449003
  CAS Number: CAS 101-31-5
  TTD Drug ID: D0RD5W

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Ascorbate and aldarate metabolism	-1.63	4.88e-2	15/30 (50%)	ALDH7A1;RGN;ALDH9A1;...
Cholesterol metabolism	-1.63	4.79e-2	44/50 (88%)	LPL;APOC3;APOE;...
Lipid and atherosclerosis	-1.63	4.94e-2	190/215 (88.37%)	MAPK14;TLR4;MMP1;...
Arginine and proline metabolism	-1.68	2.93e-2	39/50 (78%)	ALDH7A1;ALDH9A1;AOC1;...
Biosynthesis of unsaturated fatty acids	-1.68	2.93e-2	21/27 (77.78%)	HSD17B12;ACOX1;ACOX3;...
Fluid shear stress and atherosclerosis	-1.69	2.83e-2	123/139 (88.49%)	PDGFA;SUMO1;GSTA1;...
Retinol metabolism	-1.70	2.58e-2	41/68 (60.29%)	ADH1C;UGT2B28;ADH6;...
Mineral absorption	-1.71	2.31e-2	48/60 (80%)	HMOX1;ATP2B4;SLC39A4;...
beta-Alanine metabolism	-1.71	2.38e-2	25/30 (83.33%)	ACOX1;ACOX3;MLYCD;...
Systemic lupus erythematosus	-1.71	2.40e-2	45/135 (33.33%)	TRIM21;IL10;HLA-DOB;...
Terpenoid backbone biosynthesis	-1.72	2.54e-2	18/22 (81.82%)	PMVK;IDI1;GGPS1;...
Steroid hormone biosynthesis	-1.77	1.95e-2	43/61 (70.49%)	UGT2B28;HSD17B12;HSD17B1;...
Drug metabolism	-1.77	2.08e-2	78/151 (51.66%)	ADH7;CYP2C8;DPYS;...
Protein processing in endoplasmic reticulum	-1.77	2.22e-2	127/171 (74.27%)	ERO1B;DNAJC3;RPN1;...
Fatty acid degradation	-1.77	2.16e-2	40/43 (93.02%)	ACADVL;ACOX1;ACOX3;...
Metabolism of xenobiotics by cytochrome P450	-1.79	1.93e-2	49/77 (63.64%)	ADH7;UGT2B4;ADH1B;...
Pentose phosphate pathway	-1.82	1.55e-2	25/30 (83.33%)	TKT;TALDO1;ALDOB;...
Peroxisome	-1.85	1.11e-2	72/82 (87.8%)	SOD2;PEX13;ACOX3;...
Ferroptosis	-1.88	7.81e-3	36/41 (87.8%)	MAP1LC3B;FTH1;STEAP3;...
Tryptophan metabolism	-1.91	7.54e-3	35/42 (83.33%)	HADHA;ALDH7A1;KMO;...
Pyruvate metabolism	-1.92	7.18e-3	41/47 (87.23%)	ADH7;ADH1B;MDH1;...
Glycolysis / Gluconeogenesis	-1.94	8.37e-3	56/67 (83.58%)	MINPP1;ADH7;ALDOB;...
Histidine metabolism	-1.98	6.03e-3	16/22 (72.73%)	ALDH7A1;HAL;ALDH9A1;...
Valine, leucine and isoleucine degradation	-2.02	2.51e-3	42/48 (87.5%)	ACAA2;AUH;AOX1;...
Staphylococcus aureus infection	-2.03	3.35e-3	72/95 (75.79%)	KRT24;ITGB2;PLG;...
PPAR signaling pathway	-2.07	5.02e-3	66/74 (89.19%)	MMP1;ACOX3;CPT1A;...
Complement and coagulation cascades	-2.30	0.00e+0	76/85 (89.41%)	C8A;C5AR1;C8B;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	6.66uM - 10uM	6H	Hide ▲

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	10uM	6H, 24H	Show ▼

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ASC	CVCL_U602	Homo sapiens	10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	10uM	6H, 24H	Show ▼

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	10uM	6H	Show ▼

Hepatocellular carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HuH-7	CVCL_0336	Homo sapiens	12uM	72H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	10uM	6H, 24H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H, 24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	10uM	6H, 24H	Show ▼