Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM81D4I)

Drug Name
PF-4447943 Drug Info
Synonyms BCP16255
Cross-matching ID
PubChem CID
135564558
ChEBI ID
CHEMBL2179105
CAS Number
CAS 1082744-20-4
TTD Drug ID
D0A9IY

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 1.97 9.92e-3 34/36 (94.44%) POLE2;POLE3;MCM4;...
Circadian rhythm -1.70 4.64e-2 26/31 (83.87%) PRKAB1;PER2;RORA;...
Allograft rejection -1.71 4.70e-2 32/38 (84.21%) CD28;FAS;HLA-B;...
Tuberculosis -1.72 4.79e-2 159/180 (88.33%) EP300;TGFB2;MAPK14;...
Phagosome -1.75 4.03e-2 118/152 (77.63%) SFTPD;ATP6V1B2;HLA-B;...
Mitophagy -1.75 4.53e-2 56/68 (82.35%) GABARAPL2;BECN1;GABARAPL1;...
Osteoclast differentiation -1.77 4.03e-2 117/127 (92.13%) LILRB4;TGFB2;MAPK14;...
Th1 and Th2 cell differentiation -1.93 2.02e-2 80/92 (86.96%) NFKBIE;CD3G;MAPK14;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H