Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM82Z30)

• Drug Name: Topiramate Drug Info
• Synonyms: Epitoma; Epitomax; TOR; Tipiramate; Tipiramato; Topamac; Topamax; Topimax; Topina; Topiramato; Topiramatum; Topomax; Cilag brandof topiramate; Janssen brand of topiramate; Ortho brand of topiramate; Tipiramate [French]; Tipiramato [Spanish]; Topamax Sprinkle; Topiramate tablet; Topiramatum [Latin]; Topiramic acid; McN 4853; RWJ 17021; KS-1122; KW-6485; McN-4853; RWJ-17021; Topamax (TN); Topamax, Topiramate; Topiramate (TPM); Topiramate / Placebo; Topiramato [INN-Spanish]; Topiramatum [INN-Latin]; USL-255; RWJ-17021-000; Topiramate [USAN:BAN:INN]; Topiramate (JAN/USAN/INN); Beta-D-Fructopyranose, 2,3:4,5-bis-O-(1-methylethylidene)-, sulfamate; Beta-D-Fructopyranose, 2,3:4,5-bis-O-(1-methylethylidene)-, sulfamate (9CI);Beta.-D-Fructopyranose, 2,3:4,5-bis-O-(1-methylethylidene)-, 1-sulfamate; [(3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl]methyl sulfamate; 2,3-4,5-bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate; 2,3:4,5-Bis-O-(1-methylethylidene) .beta.-D-fructopyranose sulfamate; 2,3:4,5-Bis-O-(1-methylethylidene)-36-D-fructo-pyranose sulfamate; 2,3:4,5-Bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate; 2,3:4,5-Di-O-isopropylidene-(beta)-D-fructopyranose sulfamate; 2,3:4,5-Di-O-isopropylidene-beta-D-fructopyranose sulfamate; 5H-Bis[1,3]dioxolo[4,5-b:4',5'-d]pyran, beta
• Therapeutic Class: Anticonvulsants
• Cross-matching ID:
  PubChem CID: 5284627
  ChEBI ID: CHEMBL220492
  CAS Number: CAS 97240-79-4
  TTD Drug ID: D07VDZ
  VARIDT Drug ID: DR01372
  INTEDE Drug ID: DR1618
  ACDINA Drug ID: D00689

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Proteasome	2.37	0.00e+0	44/46 (95.65%)	PSMA6;PSMB3;PSMB6;...
DNA replication	2.27	0.00e+0	34/36 (94.44%)	RPA3;MCM5;POLE2;...
Pyrimidine metabolism	2.16	0.00e+0	40/56 (71.43%)	ENPP1;NME1;RRM2;...
Nucleotide excision repair	2.05	2.71e-3	40/47 (85.11%)	RPA3;RBX1;POLE2;...
Purine metabolism	1.90	6.49e-3	102/129 (79.07%)	AK4;HPRT1;NUDT9;...
Ribosome	1.87	9.02e-3	113/158 (71.52%)	MRPL15;MRPL13;MRPL22;...
Mismatch repair	1.85	9.27e-3	22/23 (95.65%)	RPA3;RPA2;RFC2;...
Parkinson disease	1.85	9.47e-3	176/249 (70.68%)	DAXX;PSMA6;EIF2S1;...
Thiamine metabolism	1.82	1.20e-2	12/15 (80%)	AK4;AK1;ALPL;...
Nitrogen metabolism	1.80	1.30e-2	16/17 (94.12%)	CA2;GLUD2;GLUD1;...
Huntington disease	1.80	1.28e-2	233/306 (76.14%)	PSMA6;POLR2D;NDUFA9;...
Cell cycle	1.75	1.80e-2	110/124 (88.71%)	CDC20;RBX1;MCM5;...
Mineral absorption	1.69	3.75e-2	48/60 (80%)	MT1M;CYBRD1;MT1F;...
Ribosome biogenesis in eukaryotes	1.67	4.79e-2	52/108 (48.15%)	RPP40;POP4;NXT1;...
Porphyrin and chlorophyll metabolism	1.66	4.76e-2	23/43 (53.49%)	HMBS;UGT2B28;HCCS;...
Amyotrophic lateral sclerosis	1.65	4.94e-2	267/364 (73.35%)	DAXX;PSMA6;EIF2S1;...
Notch signaling pathway	-1.98	0.00e+0	49/59 (83.05%)	TLE3;HEY2;DVL2;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	6H, 24H	Hide ▲

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	3H, 24H	Hide ▲

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.04uM - 10uM	6H, 24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼