Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM83HWL)

Drug Name
L-thyroxine Drug Info
Synonyms
DL-Thyroxin; L-3,5,3',5'-Tetraiodothyronine; L-Thyroxin; L-thyroxine; Laevothyroxinum; Laevothyroxinum (acid); Levothyroxin; Levothyroxinum (acid); T4 (Hormone); Tetraiodothyronine; Tetramet; Thyratabs; Thyrax; Thyreoideum; Thyroxinal; Thyroxine (VAN); Thyroxine (l); Thyroxine I 125; Thyroxine iodine; levothyroxine; thyroxin; thyroxine; (-)-Thyroxine; 3,3',5,5'-Tetraiodo-L-thyronine; 3,5,3',5'-Tetraiodo-L-thyronine; 3,5,3',5'-Tetraiodothyronine; 51-48-9; L-T4; t4
Cross-matching ID
PubChem CID
5819
ChEBI ID
CHEMBL1624
CAS Number
CAS 51-48-9
INTEDE Drug ID
DR1950

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.39 0.00e+0 34/36 (94.44%) MCM3;RNASEH2A;MCM5;...
Cell cycle 2.16 0.00e+0 110/124 (88.71%) GADD45B;MCM3;SMAD3;...
Spliceosome 2.07 7.69e-3 101/150 (67.33%) SRSF1;PUF60;HNRNPM;...
Glyoxylate and dicarboxylate metabolism 1.93 5.77e-3 23/30 (76.67%) DLD;CS;ACO1;...
Ribosome biogenesis in eukaryotes 1.90 6.92e-3 52/108 (48.15%) DKC1;EIF6;NAT10;...
One carbon pool by folate 1.84 1.54e-2 15/20 (75%) TYMS;DHFR;AMT;...
p53 signaling pathway 1.81 1.98e-2 63/73 (86.3%) GADD45B;IGF1;CCND1;...
Mismatch repair 1.80 2.02e-2 22/23 (95.65%) LIG1;MSH6;MLH1;...
Aminoacyl-tRNA biosynthesis 1.78 1.92e-2 15/66 (22.73%) FARSA;QRSL1;CARS2;...
Citrate cycle (TCA cycle) 1.76 1.96e-2 30/30 (100%) IDH3A;DLD;ACLY;...
Chronic myeloid leukemia 1.73 3.04e-2 72/76 (94.74%) SHC1;GADD45B;TGFBR2;...
RNA transport 1.73 2.79e-2 128/186 (68.82%) PNN;EIF2S3;FMR1;...
Lysine degradation 1.68 4.35e-2 51/63 (80.95%) PLOD2;DLD;ALDH3A2;...
Oocyte meiosis 1.65 5.00e-2 90/129 (69.77%) AR;PPP3CA;IGF1;...
mRNA surveillance pathway 1.65 4.90e-2 71/98 (72.45%) PNN;PAPOLA;EIF4A3;...
Cytokine-cytokine receptor interaction -1.70 4.83e-2 246/295 (83.39%) NGFR;IL10RA;IL23A;...
Legionellosis -1.77 2.78e-2 51/57 (89.47%) CASP7;NFKB2;IL6;...
Malaria -1.77 3.16e-2 44/50 (88%) IL1B;HGF;ICAM1;...
Rheumatoid arthritis -1.77 3.95e-2 78/93 (83.87%) CD80;IL23A;ATP6V1G1;...
IL-17 signaling pathway -1.82 3.80e-2 84/94 (89.36%) LCN2;MUC5B;S100A9;...
NF-kappa B signaling pathway -1.91 2.19e-2 90/104 (86.54%) NFKB2;TRAF5;BLNK;...
Mineral absorption -2.08 8.77e-3 48/60 (80%) ATP2B2;MT1G;ATP1B2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 4uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 10uM 24H