Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM89JLN)

Drug Name
Apixaban Drug Info
Synonyms
GG2; BMS 562247-01; BMS-562247; Eliquis (TN); BMS-562247-01; Apixaban (JAN/USAN/INN); BMS-562247-01, Apixaban; Ro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahyd
Cross-matching ID
PubChem CID
10182969
ChEBI ID
CHEMBL231779
CAS Number
CAS 503612-47-3
TTD Drug ID
D0I5HF
VARIDT Drug ID
DR00211
INTEDE Drug ID
DR0122
ACDINA Drug ID
D00040

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 1.85 2.59e-2 34/36 (94.44%) POLE2;PCNA;FEN1;...
Estrogen signaling pathway -1.68 3.27e-2 119/137 (86.86%) PLCB4;MAPK3;MMP9;...
Viral myocarditis -1.69 3.18e-2 53/60 (88.33%) HLA-DRA;HLA-DPB1;CD86;...
Neutrophil extracellular trap formation -1.69 3.24e-2 101/189 (53.44%) HDAC3;GP1BA;C5AR1;...
Pentose and glucuronate interconversions -1.70 3.08e-2 17/34 (50%) AKR1B1;UGDH;CRYL1;...
Type I diabetes mellitus -1.75 1.98e-2 38/43 (88.37%) HLA-DRA;HLA-DPB1;CD86;...
Influenza A -1.75 2.06e-2 156/172 (90.7%) IL12B;TRADD;OAS3;...
Non-small cell lung cancer -1.76 1.96e-2 70/72 (97.22%) FOXO3;RXRA;STAT5B;...
Antigen processing and presentation -1.76 1.97e-2 60/78 (76.92%) HLA-DRA;HLA-DPB1;HLA-G;...
Leukocyte transendothelial migration -1.76 2.06e-2 90/114 (78.95%) MMP9;CLDN8;JAM2;...
Natural killer cell mediated cytotoxicity -1.77 2.16e-2 99/131 (75.57%) PTPN11;IFNAR2;KRAS;...
Toll-like receptor signaling pathway -1.78 1.97e-2 94/104 (90.38%) IL12B;STAT1;MYD88;...
Bladder cancer -1.80 1.43e-2 40/41 (97.56%) MAPK3;MMP9;FGFR3;...
Legionellosis -1.81 1.26e-2 51/57 (89.47%) HSPD1;HSPA1A;CASP1;...
Kaposi sarcoma-associated herpesvirus infection -1.82 1.07e-2 172/193 (89.12%) IFNAR2;CASP8;KRAS;...
Allograft rejection -1.83 1.04e-2 32/38 (84.21%) IL12B;HLA-DRA;HLA-DPB1;...
Amino sugar and nucleotide sugar metabolism -1.85 1.01e-2 38/48 (79.17%) CYB5R4;NANS;HK3;...
Viral protein interaction with cytokine and cytokine re... -1.89 8.65e-3 84/100 (84%) TNFSF10;CXCR3;IL2RA;...
NF-kappa B signaling pathway -1.89 9.31e-3 90/104 (86.54%) PIDD1;TNFSF11;IRAK4;...
Epithelial cell signaling in Helicobacter pylori infect... -1.91 7.57e-3 62/70 (88.57%) ATP6V0E1;ATP6V1H;ATP6V0B;...
Fructose and mannose metabolism -1.91 8.26e-3 30/33 (90.91%) HK1;TPI1;GMDS;...
Epstein-Barr virus infection -1.93 4.54e-3 189/202 (93.56%) TRADD;OAS3;STAT1;...
NOD-like receptor signaling pathway -1.94 3.36e-3 145/181 (80.11%) OAS3;STAT1;MYD88;...
Graft-versus-host disease -1.97 1.89e-3 32/42 (76.19%) HLA-DRA;HLA-DPB1;CD86;...
Chemokine signaling pathway -1.98 2.16e-3 163/192 (84.9%) ADCY8;STAT5B;HCK;...
Primary immunodeficiency -2.00 2.52e-3 33/38 (86.84%) CD3D;CIITA;AICDA;...
IL-17 signaling pathway -2.01 3.03e-3 84/94 (89.36%) HSP90AA1;MUC5B;TRAF3IP2;...
Lipid and atherosclerosis -2.09 3.78e-3 190/215 (88.37%) TLR2;IL1B;JAK2;...
TNF signaling pathway -2.10 5.05e-3 103/112 (91.96%) ATF2;CFLAR;TRAF3;...
Rheumatoid arthritis -2.11 0.00e+0 78/93 (83.87%) HLA-DRA;HLA-DPB1;CD86;...
Intestinal immune network for IgA production -2.19 0.00e+0 38/48 (79.17%) HLA-DRA;HLA-DPB1;CD86;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H