Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM89QE1)

Drug Name
Metformin Drug Info
Synonyms
657-24-9; 1,1-Dimethylbiguanide; N,N-dimethylimidodicarbonimidic diamide; Metiguanide; Dimethylbiguanide; Glucophage; Haurymelin; Gliguanid; Fluamine; Glumetza; Flumamine; Melbin; Diabex; N,N-Dimethylbiguanide; Metformina; Metforminum; Metformine; Islotin; Glifage; Siofor; N1,N1-Dimethylbiguanide; DMGG; NNDG; Dimethyldiguanide; N,N-Dimethyldiguanide; Metformina [DCIT]; Imidodicarbonimidic diamide, N,N-dimethyl-; Metformina [Spanish]; Metforminum [INN-Latin]; Metformine [INN-French]; Metformin [USAN:INN:BAN]; 1,1-Dimethyl; Diabetosan; Dimethylbiguanidine; Dimethylguanylguanidine; Glycon; Diabex (TN); Diaformin (TN); Dianben (TN); Fortamet (TN); Gen-Metformin; Glucophage (TN); Glumetza (TN); LA-6023; Nu-Metformin; Obimet (TN); Riomet (TN); Metformin (USAN/INN); 1,1-Dimethyl biguanide; 3-(diaminomethylidene)-1,1-dimethylguanidine; [14C]metformin
Therapeutic ClassHypoglycemic Agents
Cross-matching ID
PubChem CID
4091
ChEBI ID
CHEMBL1431
CAS Number
CAS 657-24-9
TTD Drug ID
D0D7LA
VARIDT Drug ID
DR00133
ACDINA Drug ID
D00405

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Cell cycle 2.02 0.00e+0 110/124 (88.71%) CDC20;CCNE1;MCM7;...
Fanconi anemia pathway 1.94 4.36e-3 36/54 (66.67%) REV3L;FANCL;RAD51;...
Pertussis -1.63 4.87e-2 64/76 (84.21%) C1QB;TNF;ITGB1;...
Sphingolipid metabolism -1.64 4.95e-2 32/49 (65.31%) SGMS1;GLA;PSAP;...
Glycolysis / Gluconeogenesis -1.69 3.34e-2 56/67 (83.58%) PGM1;PDHB;BPGM;...
Pentose phosphate pathway -1.70 3.15e-2 25/30 (83.33%) PGM1;G6PD;GPI;...
Biosynthesis of unsaturated fatty acids -1.71 3.14e-2 21/27 (77.78%) HSD17B4;FADS1;ELOVL5;...
Leukocyte transendothelial migration -1.72 3.21e-2 90/114 (78.95%) PIK3CA;MYL7;RAC1;...
Phagosome -1.72 3.36e-2 118/152 (77.63%) HLA-DOA;ATP6V0D1;ATP6AP1;...
Cholesterol metabolism -1.72 3.28e-2 44/50 (88%) LRP2;CYP27A1;ANGPTL8;...
Rheumatoid arthritis -1.74 2.82e-2 78/93 (83.87%) IL17A;ATP6V0E2;CSF1;...
Lysosome -1.76 2.48e-2 115/128 (89.84%) CTSF;CTSO;AGA;...
Glycine, serine and threonine metabolism -1.77 1.75e-2 31/40 (77.5%) CBS;AGXT;GNMT;...
Peroxisome -1.82 1.34e-2 72/82 (87.8%) PEX16;ACSL4;EHHADH;...
Ferroptosis -1.85 1.23e-2 36/41 (87.8%) ATG7;GCLC;PCBP2;...
Ascorbate and aldarate metabolism -1.87 1.25e-2 15/30 (50%) UGT2B28;UGDH;UGT2B4;...
Metabolism of xenobiotics by cytochrome P450 -1.92 5.47e-3 49/77 (63.64%) GSTK1;SULT2A1;CYP3A5;...
Sulfur metabolism -1.99 4.37e-3 9/10 (90%) MPST;SELENBP1;PAPSS2;...
Pentose and glucuronate interconversions -2.04 0.00e+0 17/34 (50%) DCXR;UGT2B28;UGDH;...
Amino sugar and nucleotide sugar metabolism -2.06 0.00e+0 38/48 (79.17%) GMDS;HEXA;GALE;...
Steroid hormone biosynthesis -2.09 0.00e+0 43/61 (70.49%) HSD3B2;CYP21A2;HSD17B2;...
Complement and coagulation cascades -2.64 0.00e+0 76/85 (89.41%) CFHR5;C8A;C8G;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.37uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Fibroblast
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
FIBRNPC CVCL_UK07 Homo sapiens 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
HEK293T CVCL_0063 Homo sapiens 0.125uM - 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 24H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 25uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 2.22uM 24H