Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM8AI9U)

• Drug Name: Loxapine Drug Info
• Synonyms: Cloxazepine; Dibenzacepin; Dibenzoazepine; Lossapina; Loxapin; Loxapina; Loxapinsuccinate; Loxapinum; Loxepine; Oxilapine; Lossapina [DCIT]; Loxitane IM; CL 62362; HF 3170; HF3170; Hydrofluoride 3170; LW 3170; S 805; SUM 3170; CL-62362; Loxapac (TN); Loxapina [INN-Spanish]; Loxapinum [INN-Latin]; Loxitane (TN); S-805;SUM-3170; CL-71,563; Loxapine (USAN/INN); Loxapine [USAN:BAN:INN]; Loxapine [USAN:INN:BAN]; 2-Chloro-11-(4-methyl-1-piperazinyl)-dibenz(b,f)(1,4)oxazepine; 2-Chloro-11-(4-methyl-1-piperazinyl)dibenz(b,f)(1,4)oxazepine; 2-Chloro-11-(4-methylpiperazino)dibenzo(b,f)(1,4)oxazepine; 2-chloro-11-(4-methylpiperazin-1-yl)dibenzo[b,f][1,4]oxazepine; 8-chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzoxazepine; 8-chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,5]benzoxazepine
• Therapeutic Class: Antipsychotic Agents
• Cross-matching ID:
  PubChem CID: 3964
  ChEBI ID: CHEMBL831
  CAS Number: CAS 1977-10-2
  TTD Drug ID: D0U5OE
  INTEDE Drug ID: DR0989
  ACDINA Drug ID: D00379

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Steroid biosynthesis	2.35	0.00e+0	19/20 (95%)	SQLE;DHCR24;MSMO1;...
Fatty acid biosynthesis	1.92	1.41e-2	16/18 (88.89%)	FASN;ACSL1;ACACA;...
Ribosome	1.90	1.41e-2	113/158 (71.52%)	RPS4Y1;RPL10;MRPL15;...
Ribosome biogenesis in eukaryotes	1.82	2.64e-2	52/108 (48.15%)	FBL;RCL1;NHP2;...
Proteasome	1.80	2.39e-2	44/46 (95.65%)	PSMA7;PSMD8;PSMD6;...
Tyrosine metabolism	1.77	2.58e-2	30/36 (83.33%)	MAOA;MAOB;ADH1B;...
Complement and coagulation cascades	1.71	4.22e-2	76/85 (89.41%)	C3;C1QB;CFD;...
Phenylalanine metabolism	1.70	4.92e-2	14/17 (82.35%)	MAOA;MAOB;AOC3;...
RNA polymerase	1.68	4.77e-2	23/31 (74.19%)	POLR3C;POLR3K;POLR1C;...
Spliceosome	1.67	4.71e-2	101/150 (67.33%)	HSPA2;SRSF7;PUF60;...
Epithelial cell signaling in Helicobacter pylori infect...	-1.98	1.28e-2	62/70 (88.57%)	CHUK;CDC42;CXCL2;...
TNF signaling pathway	-2.04	4.27e-3	103/112 (91.96%)	SOCS3;PIK3R2;MAPK9;...
Rheumatoid arthritis	-2.10	0.00e+0	78/93 (83.87%)	CCL20;ATP6V1C1;CTSL;...
IL-17 signaling pathway	-2.11	0.00e+0	84/94 (89.36%)	IL5;MMP13;TNF;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	10uM	6H	Hide ▲

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	10uM	6H	Show ▼

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ASC	CVCL_U602	Homo sapiens	10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	10uM	6H, 24H	Show ▼

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	10uM	6H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	10uM	6H, 24H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H, 24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	10uM	6H	Show ▼