Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM8BKU9)

• Drug Name: Acitretin Drug Info
• Synonyms: Acitretina; Acitretine; Acitretinum; Etretin; Isoacitretin; Isoetretin; Neotigason; Soriatane; TMMP; Acitretina [Spanish]; Acitretine [French]; Acitretinum [Latin]; Retinoid etretin; U0279; Ro 10-1670; Ro 13-7652; Soriatane (TN); Soriatane, Acitretin; Acitretin (USAN/INN); Acitretin [USAN:INN:BAN]; All-trans-Acitretin; Ro 10-1670/000; Ro-10-1670; Ro-13-7652; Ro-10-1670/000; All-trans-3,7-Dimethyl-9-(4-methoxy-2,3,6-trimethylphenyl)-2,4,6,8-nonatetraenoic acid; (2E,4E,6E,8E)-3,7-dimethyl-9-[2,3,6-trimethyl-4-(methyloxy)phenyl]nona-2,4,6,8-tetraenoic acid; (2E,4E,6E,8E)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid; (all-E)-9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic acid; 13-cis-Acitretin; 9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic acid; 9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid
• Therapeutic Class: Keratolytic Agents
• Cross-matching ID:
  PubChem CID: 5284513
  ChEBI ID: CHEMBL1131
  CAS Number: CAS 55079-83-9
  TTD Drug ID: D05QDC
  VARIDT Drug ID: DR00827
  ACDINA Drug ID: D00012

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Ribosome biogenesis in eukaryotes	1.96	3.41e-2	52/108 (48.15%)	NOP56;NVL;RPP38;...
Legionellosis	1.95	1.71e-2	51/57 (89.47%)	HSPA8;TLR4;C3;...
Cytosolic DNA-sensing pathway	1.93	1.14e-2	52/63 (82.54%)	CCL5;IL1B;POLR3B;...
Leishmaniasis	1.93	8.53e-3	67/77 (87.01%)	TLR4;C3;JAK1;...
IL-17 signaling pathway	1.93	6.83e-3	84/94 (89.36%)	S100A8;S100A9;CCL2;...
Chagas disease	1.90	5.69e-3	93/102 (91.18%)	GNAS;TLR4;CCL5;...
Spliceosome	1.89	4.88e-3	101/150 (67.33%)	HSPA8;SRSF7;LSM2;...
Amoebiasis	1.84	7.11e-3	99/102 (97.06%)	LAMB1;GNAS;TLR4;...
Influenza A	1.83	6.32e-3	156/172 (90.7%)	TLR4;CCL5;CCL2;...
NOD-like receptor signaling pathway	1.83	5.69e-3	145/181 (80.11%)	TLR4;IFI16;CCL5;...
Malaria	1.80	1.03e-2	44/50 (88%)	TLR4;CCL2;IL1B;...
NF-kappa B signaling pathway	1.74	2.75e-2	90/104 (86.54%)	TLR4;TNFAIP3;IL1B;...
DNA replication	1.72	3.41e-2	34/36 (94.44%)	RFC5;PCNA;RFC3;...
Fatty acid elongation	-1.70	4.58e-2	19/27 (70.37%)	HSD17B12;HACD3;HADHA;...
Butanoate metabolism	-1.74	3.24e-2	23/28 (82.14%)	GAD2;ACADS;ACSM5;...
Steroid hormone biosynthesis	-1.78	2.47e-2	43/61 (70.49%)	CYP1A2;AKR1D1;CYP2E1;...
Collecting duct acid secretion	-1.78	2.97e-2	22/27 (81.48%)	ATP6V1F;ATP6V1G1;ATP6V0D1;...
Primary bile acid biosynthesis	-1.80	3.05e-2	15/17 (88.24%)	CYP7A1;BAAT;CYP7B1;...
Porphyrin and chlorophyll metabolism	-1.82	2.91e-2	23/43 (53.49%)	COX15;ALAD;UGT2B4;...
Renin-angiotensin system	-1.83	4.36e-2	20/23 (86.96%)	REN;CTSG;ATP6AP2;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	10uM	6H	Hide ▲

Fibroblast

Nasopharyngeal carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
FIBRNPC	CVCL_UK07	Homo sapiens	10uM	6H, 24H	Show ▼

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ASC	CVCL_U602	Homo sapiens	10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	10uM	6H	Show ▼

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
1HAEo-	CVCL_0128	Homo sapiens	10uM	24H	Show ▼
NL20	CVCL_0461	Homo sapiens	10uM	24H	Show ▼

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	10uM	6H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	10uM	6H, 24H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H	Show ▼

Normal (Fibroblast)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HFL1	CVCL_4295	Homo sapiens	10uM	24H	Show ▼
IMR-90	CVCL_0347	Homo sapiens	10uM	24H	Show ▼
WI-38	CVCL_0579	Homo sapiens	10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	10uM	6H	Show ▼