Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM8C2Z0)

Drug Name
RO-194603 Drug Info
Synonyms
Ro 19-4603; 99632-94-7; Ro-19-4603; 5,6-DIHYDRO-5-METHYL-6-OXO-4H-IMIDAZO[1,5-A]THIENO[2,3-F][1,4]DIAZEPINE-3-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER; Tocris-1995; AC1L2RWP; tert-butyl 5-methyl-6-oxo-5,6-dihydro-4h-imidazo[1,5-a]thieno[2,3-f][1,4]diazepine-3-carboxylate; RO-194603; CHEMBL269366; CHEBI:34952; RO19-4603; ZIGMMUKDYCABPW-UHFFFAOYSA-N; AC1Q5XKN; C13716; SCHEMBL2464268; GTPL4297; ZINC3945; CTK8D8286; DTXSID90244173; MolPort-023-276-300; HMS3268D07; PDSP1_001769; PDSP2_001752; BDBM50034835; AKOS024456899; NCGC00025337-01
Cross-matching ID
PubChem CID
127382
ChEBI ID
CHEMBL34952
CAS Number
CAS 99632-94-7
TTD Drug ID
D0UQ6J

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Ribosome 2.35 0.00e+0 113/158 (71.52%) RPS4Y1;RPL10;RPL26;...
Spliceosome 1.91 2.68e-2 101/150 (67.33%) SRSF5;SRSF7;RBMX;...
Dilated cardiomyopathy -1.83 4.31e-2 86/96 (89.58%) CACNA1S;CACNB4;MYL3;...
Cortisol synthesis and secretion -1.86 4.71e-2 58/65 (89.23%) KCNK3;PBX1;GNAS;...
Viral protein interaction with cytokine and cytokine re... -1.96 2.35e-2 84/100 (84%) CCL8;CXCR4;TNFRSF1A;...
×

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H