Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM8EVK5)

Drug Name
Wortmannin Drug Info
Synonyms
wortmannin; 19545-26-7; Wartmannin; KY 12420; Antibiotic SL-2052; SL-2052; UNII-XVA4O219QW; NSC221019; XVA4O219QW; MLS002703028; CHEMBL428496; CHEBI:52289; Wortmannin, 98%; Pi 3-Kinase Inhibitor; NSC 627609; BRN 0067676; (1S,6bR,9aS,11R,11bR)-9a,11b-dimethyl-1-[(methyloxy)methyl]-3,6,9-trioxo-1,6,6b,7,8,9,9a,10,11,11b-decahydro-3H-furo[4,3,2-de]indeno[4,5-h]isochromen-11-yl acetate
Cross-matching ID
PubChem CID
312145
ChEBI ID
CHEMBL428496
CAS Number
CAS 19545-26-7
TTD Drug ID
D0P1JI

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Notch signaling pathway 2.27 0.00e+0 49/59 (83.05%) TLE1;JAG1;CREBBP;...
ECM-receptor interaction 2.12 0.00e+0 80/88 (90.91%) ITGB4;ITGB5;FN1;...
Complement and coagulation cascades 2.06 0.00e+0 76/85 (89.41%) TFPI;CFB;F13A1;...
Lysosome 2.05 0.00e+0 115/128 (89.84%) TPP1;CTSA;CTSF;...
MicroRNAs in cancer 1.83 2.65e-2 146/310 (47.1%) IRS2;ERBB2;EFNA1;...
Coronavirus disease 1.80 3.09e-2 215/232 (92.67%) NFKBIA;CFB;F13A1;...
Ovarian steroidogenesis 1.79 2.65e-2 41/51 (80.39%) IGF1R;GNAS;INSR;...
Focal adhesion 1.76 3.15e-2 180/201 (89.55%) ERBB2;PDGFD;IGF1R;...
Glycosaminoglycan degradation 1.75 3.24e-2 19/19 (100%) HGSNAT;GUSB;NAGLU;...
Sulfur metabolism 1.75 3.18e-2 9/10 (90%) TST;PAPSS2;MPST;...
Other glycan degradation 1.74 2.89e-2 13/18 (72.22%) MAN2C1;FUCA1;HEXA;...
Proteoglycans in cancer 1.74 3.09e-2 172/205 (83.9%) ERBB2;ERBB3;EIF4B;...
Axon guidance 1.73 2.96e-2 151/182 (82.97%) SEMA3C;EFNA1;PTCH1;...
Regulation of lipolysis in adipocytes 1.68 4.92e-2 52/55 (94.55%) IRS2;MGLL;IRS1;...
PI3K-Akt signaling pathway 1.68 4.86e-2 317/354 (89.55%) ERBB2;EFNA1;IRS1;...
MAPK signaling pathway 1.67 4.80e-2 272/294 (92.52%) ERBB2;EFNA1;DUSP4;...
Fructose and mannose metabolism -1.52 4.74e-2 30/33 (90.91%) HK3;GMPPA;ALDOB;...
Protein processing in endoplasmic reticulum -1.56 3.83e-2 127/171 (74.27%) NGLY1;VCP;DNAJC3;...
Pyrimidine metabolism -1.67 1.53e-2 40/56 (71.43%) DCK;TYMS;RRM1;...
Cysteine and methionine metabolism -1.67 1.58e-2 43/50 (86%) DNMT3B;LDHB;CTH;...
Ribosome -1.68 1.42e-2 113/158 (71.52%) MRPL2;MRPS2;MRPL4;...
Citrate cycle (TCA cycle) -1.71 1.26e-2 30/30 (100%) SDHC;DLST;SUCLA2;...
Fanconi anemia pathway -1.71 1.32e-2 36/54 (66.67%) BRIP1;RPA1;BLM;...
Folate biosynthesis -1.71 1.29e-2 23/26 (88.46%) TPH1;FPGS;MOCOS;...
Progesterone-mediated oocyte maturation -1.74 1.11e-2 75/100 (75%) CDC25C;CDC23;MAPK1;...
Protein export -1.79 6.27e-3 17/23 (73.91%) SEC61A1;SRPRA;SPCS1;...
Thiamine metabolism -1.79 6.58e-3 12/15 (80%) ACP1;TPK1;AK2;...
Spinocerebellar ataxia -1.80 6.58e-3 128/143 (89.51%) MAPK9;GTF2B;PSMC5;...
Amyotrophic lateral sclerosis -1.80 6.95e-3 267/364 (73.35%) SEM1;DCTN5;NDUFB8;...
Homologous recombination -1.81 6.58e-3 35/41 (85.37%) PALB2;NBN;BRCA1;...
Oocyte meiosis -1.82 5.76e-3 90/129 (69.77%) ADCY7;PPP1CA;RPS6KA3;...
RNA degradation -1.87 3.51e-3 53/79 (67.09%) C1D;DCPS;LSM7;...
Nucleotide excision repair -1.87 3.76e-3 40/47 (85.11%) POLD3;GTF2H1;LIG1;...
Basal transcription factors -1.89 3.04e-3 37/45 (82.22%) GTF2H1;TAF13;TAF12;...
Oxidative phosphorylation -1.92 5.48e-4 93/133 (69.92%) ATP6V0A4;ATP6V1G1;NDUFB8;...
Huntington disease -1.96 0.00e+0 233/306 (76.14%) SOD1;POLR2H;SDHC;...
Cell cycle -1.97 0.00e+0 110/124 (88.71%) ANAPC13;ORC3;E2F1;...
Mismatch repair -2.00 0.00e+0 22/23 (95.65%) POLD3;LIG1;RPA1;...
RNA polymerase -2.06 0.00e+0 23/31 (74.19%) POLR2H;POLR3F;POLR1C;...
Prion disease -2.11 0.00e+0 209/273 (76.56%) SOD1;SDHC;MAPK9;...
RNA transport -2.14 0.00e+0 128/186 (68.82%) DDX19A;NMD3;SUMO3;...
Parkinson disease -2.19 0.00e+0 176/249 (70.68%) NDUFB8;ATP5F1A;KLC2;...
Spliceosome -2.22 0.00e+0 101/150 (67.33%) TCERG1;LSM2;CTNNBL1;...
DNA replication -2.32 0.00e+0 34/36 (94.44%) RPA1;POLD1;MCM6;...
Ribosome biogenesis in eukaryotes -2.59 0.00e+0 52/108 (48.15%) EIF6;GNL2;TCOF1;...
Proteasome -2.66 0.00e+0 44/46 (95.65%) PSMC5;IFNG;PSMA5;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 10uM 6H
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NPC-B13 CVCL_D3FG Homo sapiens 10uM XH
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM - 20uM 6H
Bone marrow
Chronic myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
K-562 CVCL_0004 Homo sapiens 0.01uM - 10uM 4H, 24H
HAP1 CVCL_Y019 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 BRD4 (-) 1 CVCL_SF59 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 CDK4 (-) 1 CVCL_SI36 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 HDAC5 (-) 1 CVCL_SR11 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 ITGA4 (-) 1 CVCL_ST27 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 MAPK8 (-) 1 CVCL_SW99 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PIK3CA (-) 1 CVCL_TD60 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PRKACA (-) 1 CVCL_TG70 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PRKCQ (-) CVCL_TG92 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 RELA (-) 1 CVCL_TI75 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 SRC (-) 1 CVCL_TQ36 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 TP53 (-) 1 CVCL_RJ70 Homo sapiens 0.66uM - 3.33uM 24H
Multiple myeloma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
KMS-34 CVCL_1333 Homo sapiens 0.01uM - 10uM 24H
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NPC-BM00 CVCL_B3QC Homo sapiens 10uM XH
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.002uM - 10uM 6H, 24H, XH
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 1.11uM - 10uM 48H
Colon
Colon carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 TP53(-/-) CVCL_HD97 Homo sapiens 0.04uM - 10uM 24H
HCT 116 CVCL_0291 Homo sapiens 0.04uM - 10uM 24H
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CL-34 CVCL_1123 Homo sapiens 10uM 6H
HT-29 CVCL_0320 Homo sapiens 0.04uM - 10uM 6H, 24H
LoVo CVCL_0399 Homo sapiens 10uM 6H
MDST8 CVCL_1400 Homo sapiens 10uM 6H
NCI-H508 CVCL_1561 Homo sapiens 10uM 6H
SNU-1040 CVCL_5001 Homo sapiens 10uM 6H
SNU-C4 CVCL_5008 Homo sapiens 10uM 6H
SNU-C5 CVCL_5009 Homo sapiens 10uM 6H
SW480 CVCL_0546 Homo sapiens 10uM 6H
SW620 CVCL_0547 Homo sapiens 10uM 6H
SW948 CVCL_0550 Homo sapiens 10uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 10uM 6H
HCT 116 (Parent) CVCL_0291 Homo sapiens 0.04uM - 10uM 24H
HT115 CVCL_1294 Homo sapiens 10uM 6H
RKO CVCL_0504 Homo sapiens 10uM 6H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 10uM 6H
SNG-M CVCL_1707 Homo sapiens 10uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 10uM 6H
Fibroblast
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
FIBRNPC CVCL_UK07 Homo sapiens 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.04uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
1HAEo- CVCL_0128 Homo sapiens 0.04uM - 10uM 24H
NL20 CVCL_0461 Homo sapiens 0.04uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 6H, 24H, 48H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 10uM 6H, 24H
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NPC2-hTERT CVCL_B6EI Homo sapiens 10uM XH
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.002uM - 10uM 6H, 24H
DV-90 CVCL_1184 Homo sapiens 10uM 6H
SK-LU-1 CVCL_0624 Homo sapiens 10uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 10uM 6H
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 10uM 6H
T3M-10 CVCL_1729 Homo sapiens 10uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC15 CVCL_1253 Homo sapiens 10uM 6H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 10uM 6H
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 10uM 6H
Normal (Fibroblast)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HFL1 CVCL_4295 Homo sapiens 0.04uM - 10uM 24H
IMR-90 CVCL_0347 Homo sapiens 0.04uM - 10uM 24H
WI-38 CVCL_0579 Homo sapiens 0.04uM - 10uM 24H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1694 CVCL_1495 Homo sapiens 10uM 6H
NCI-H1836 CVCL_1502 Homo sapiens 10uM 6H
Lymph node
Burkitt lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BJAB CVCL_5711 Homo sapiens 0.01uM - 10uM 4H, 24H
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HBL-1 CVCL_4213 Homo sapiens 0.01uM - 10uM 4H, 24H
OCI-Ly10 CVCL_8795 Homo sapiens 0.01uM - 10uM 24H
OCI-Ly19 CVCL_8797 Homo sapiens 0.01uM - 10uM 4H, 24H
OCI-Ly3 CVCL_8796 Homo sapiens 0.01uM - 10uM 4H, 24H
TMD8 CVCL_A440 Homo sapiens 0.01uM - 10uM 4H, 24H
WSU-DLCL2 CVCL_1787 Homo sapiens 10uM 6H
Mantle cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MINO CVCL_4965 Homo sapiens 0.01uM - 10uM 24H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 10uM 6H
OV7 CVCL_1623 Homo sapiens 10uM 6H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RMG-I CVCL_1663 Homo sapiens 10uM 6H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 10uM 6H
RMUG-S CVCL_1666 Homo sapiens 10uM 6H
Ovarian undifferentiated carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TYK-nu CVCL_1774 Homo sapiens 10uM 6H
Peripheral blood
Acute B-lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NALM-6 CVCL_0092 Homo sapiens 0.01uM - 10uM 24H
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 4H, 6H, 24H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HL-60 CVCL_0002 Homo sapiens 0.37uM - 10uM 6H, 24H
NOMO-1 CVCL_1609 Homo sapiens 10uM 6H, 24H
PL-21 CVCL_2161 Homo sapiens 10uM 6H
SKM-1 CVCL_0010 Homo sapiens 10uM 6H
Pharynx, nasopharynx
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NPC-TY861 CVCL_A5WW Homo sapiens 10uM XH
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 0.37uM - 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.04uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 0.04uM - 20uM 6H, 24H, 48H
Skin
Alzheimer's disease
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ND347327 CVCL_EZ03 Homo sapiens 10uM XH
Gaucher disease
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GD-iPS3 CVCL_C949 Homo sapiens 10uM XH
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 10uM 6H, 24H
SK-MEL-1 CVCL_0523 Homo sapiens 10uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 10uM 6H
SK-MEL-5 CVCL_0527 Homo sapiens 0.01uM - 10uM 24H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 10uM 6H
Unclear
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NPC-204 CVCL_A5WV Homo sapiens 10uM XH